ID   MUTS_LIMF3              Reviewed;         880 AA.
AC   B2GB17;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LAF_0513;
OS   Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) (Lactobacillus
OS   fermentum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=334390;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 3956 / LMG 18251;
RX   PubMed=18487258; DOI=10.1093/dnares/dsn009;
RA   Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T.,
RA   Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T.,
RA   Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T.,
RA   Hattori M.;
RT   "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus
RT   fermentum reveal a genomic island for reuterin and cobalamin production.";
RL   DNA Res. 15:151-161(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008937; BAG26849.1; -; Genomic_DNA.
DR   RefSeq; WP_012390970.1; NC_010610.1.
DR   AlphaFoldDB; B2GB17; -.
DR   SMR; B2GB17; -.
DR   PRIDE; B2GB17; -.
DR   EnsemblBacteria; BAG26849; BAG26849; LAF_0513.
DR   GeneID; 61200436; -.
DR   KEGG; lfe:LAF_0513; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001697; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093632"
FT   REGION          790..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..829
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  98482 MW;  E09A3F26F9505D88 CRC64;
     MASKQTPMME QYQRVKDQYP DAFLFYRLGD FYEMFNEDAV KGAQLLELTL TSRSKSKDNS
     IPMCGVPHRA VDNYVDILID KGYKVAICEQ MEDPKTTKGM VKREVTRLVT PGTTMDLAGD
     AARQNNYLTA LKQEQGGYNL AYADLSTGEL KVTKVSNEAA AINELVNLQT REVVTEPEVS
     ASLLDQLTKR NILRSTQGQV VNQAEVAYLS QDLTDAGQRD VVALLVSYLL TTQKRSLAHL
     QRAVAYQLSS FMKIDHRSKV NLELTTNLRS GKRQGTLAWL LDETKTAMGS RLLKQWLDRP
     LLDQAKIERR YDRVQELLDH YFERQNLQEE LIKVYDLERL AGRVAYGSVN GRDLIQLKTS
     LEQVPKIKYI LQTLDVPAFD DLEQALDPLE DVAGLIDRAI APEPPISVTD GGVIRDGYNH
     QLDEYRGAMQ NGKQWIADLQ EQERRATGIN NLKIGYNHVF GYYIEVTKAN IDKLPADRYE
     RKQTLVNAER FATPELKEKE SLILGAQDKS TALEYELFVK VREAVKEQID RLQKLAANLA
     ALDVIQAFAK VAEDYHFVRP SLNHDHQLQI EDGRHPVVEK FMGHQEYVPN DVLMGGDTSI
     LLITGPNMSG KSTYMRQLAL TAVMAQMGCF VPAKRAQLPI FDQIFTRIGA ADDLVSGEST
     FMVEMMEANN ALQNATADSL ILFDEIGRGT ATYDGMALAQ AIIEFVHNRV GAKTLFSTHY
     HELTALEGEL DHLQNVHVGA TEENGELVFL HKVTPGPADK SYGIHVAKLA GMPTPLLTRA
     NQILTSLEGQ ETAAVPSRGV EPPAPVIEPT PAKEQTPVKE QTTPLVEESS GQLELFATAP
     VEKKDGKADK LARQVKNLDL MSMTPMDVMN QVYKWQQNLK