ID   MUTS_LISIN              Reviewed;         860 AA.
AC   Q92BV3;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lin1440;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL596168; CAC96671.1; -; Genomic_DNA.
DR   PIR; AG1612; AG1612.
DR   RefSeq; WP_010991533.1; NC_003212.1.
DR   AlphaFoldDB; Q92BV3; -.
DR   SMR; Q92BV3; -.
DR   STRING; 272626.lin1440; -.
DR   EnsemblBacteria; CAC96671; CAC96671; CAC96671.
DR   KEGG; lin:mutS; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002513; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115108"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  98215 MW;  33E626CEF8200FC4 CRC64;
     MTEYTPMIKQ YLEIKDKYQD AFLFFRLGDF YEMFFEDALN ASQILEITLT GREGGTKEKI
     PMCGVPYHSA SGYIDTLIEK GYKVAICEQV EDPKTTKGMV KREVVQLISP GTVMDERGLK
     AKENNYIASL YCYEGKEYGF AYSDLSTGEL KSTVIEASED RLINELTTLS TRELIVSESE
     KEVLSDVMKE QLGLTFSVHE EDTIPAENEK LVTRHMSLSE KRAIGKLLHY LKETQKRDLG
     HLQQAIHYET SNYMKMDYYS KRNLELAESI RGKGRQGTLL WLLDNTQTAM GGRMLKQWID
     RPLIDRKQII ERQDDVSELM AHFFERLELV ENLKNVYDLE RLAGRVAYGN VNARDLIQLR
     NSLYQIPRIR ATLLSMNSKS LTALANQLDP CEELTEKLEE AIVDSAPISI REGGIIKDGY
     NSQLDTYRDA SRNGKTWIAE LERKERELTG IKTMKVGFNR VFGYYIEVTR ANTHLLPEGR
     YERKQTLANA ERYITPELKE KEKLILDAEE KSMELEYQLF TEVREMVKDY IERLQKLAKS
     VSEIDCLQSF ADISEKNHFI RPTLSEDGSL HVKQGRHPVV EKVMGAQSYV ANDCDLDQNR
     EILLITGPNM SGKSTYMRQV ALTAICAQVG CFVPAEEATL PIFDQIFTRI GAADDLIAGQ
     STFMVEMLEA RNAIVHATKD SLILFDEIGR GTATYDGMAL AQAIIEYIHE NVHAKTLFST
     HYHELTDLEK ELRGLQNIHV SAVEENGKVV FLHKIKEGPA DKSYGIHVAE LAELPKSLIE
     RASRILEQLE SNDKKIIITQ DKQPEEIHEE VQLSMFPVEP EEKASSKETK LLKEIAAMNI
     MQMTPMDAMN KLYELQSKIH