ID   MUTS_LISMH              Reviewed;         860 AA.
AC   B8DFS4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LMHCC_1166;
OS   Listeria monocytogenes serotype 4a (strain HCC23).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=552536;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HCC23;
RX   PubMed=21602330; DOI=10.1128/jb.05236-11;
RA   Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M.,
RA   Lawrence M.L.;
RT   "Genome sequence of lineage III Listeria monocytogenes strain HCC23.";
RL   J. Bacteriol. 193:3679-3680(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001175; ACK39514.1; -; Genomic_DNA.
DR   RefSeq; WP_012581341.1; NC_011660.1.
DR   AlphaFoldDB; B8DFS4; -.
DR   SMR; B8DFS4; -.
DR   KEGG; lmh:LMHCC_1166; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118686"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  98273 MW;  A3232332680BF79D CRC64;
     MTEYTPMIKQ YLEIKDKYQD AFLFFRLGDF YEMFFEDALN ASQILEITLT GREGGTKEKI
     PMCGVPYHSA SGYIDTLIEK GYKVAICEQV EDPKTTKGMV KREVVQLISP GTVMDERGLK
     AKENNYIASL YCYEGKEYGF AYSDLSTGEL KSTVIEASED RLINELTTLS TRELIVSASE
     KEVLSDVMKE QLGLTFSVHE EDTIPLENEK LVTRHMSLSE KRAIGKLLHY LKETQKRDLG
     HLQQAVHYET SNYMKMDYYS KRNLELAESI RGKGRQGTLL WLLDNTQTAM GGRMLKQWID
     RPLIDRNKII ERQNDVSELM ANFFERLELV ENLKNVYDLE RLAGRVAYGN VNARDLIQLR
     NSLYQIPRIR ATLLSMNSKS LTELANQLDP CEELTEKLEE AIMDSAPISI REGGIIKDGY
     NSQLDTYRDA SRNGKTWIAE LERKERELTG IKTMKVGFNR VFGYYIEVTR ANTHLLPEGR
     YERKQTLTNA ERYITPELKE KEKLILDAEE KSMELEYQLF TEVRELVKDY IERLQKLAKS
     VSEIDCLQSF ADISEKNHFI RPTLSEDGSL HVKQGRHPVV EKVMGAQSYV ANDCDLDRNR
     EILLITGPNM SGKSTYMRQV ALTAICAQVG CFVPAEEATL PIFDQIFTRI GAADDLIAGQ
     STFMVEMLEA RNAIVHATKD SLILFDEIGR GTATYDGMAL AQAIIEYIHE NVHAKTLFST
     HYHELTDLEK ELHGLQNIHV SAVEENGKVV FLHKIKEGPA DKSYGIHVAE LAELPKSLIE
     RASRILEQLE NDDKKIVITN DKQPEEIHEE VQLSMFPVEP EKKASSKETK LLKEIASMNI
     MQMTPMDAMN KLYELQSKIH