ID   MUTS_LISMO              Reviewed;         860 AA.
AC   Q8Y789;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lmo1403;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL591979; CAC99481.1; -; Genomic_DNA.
DR   PIR; AC1250; AC1250.
DR   RefSeq; NP_464928.1; NC_003210.1.
DR   RefSeq; WP_010990113.1; NC_003210.1.
DR   AlphaFoldDB; Q8Y789; -.
DR   SMR; Q8Y789; -.
DR   STRING; 169963.lmo1403; -.
DR   PaxDb; Q8Y789; -.
DR   EnsemblBacteria; CAC99481; CAC99481; CAC99481.
DR   GeneID; 985419; -.
DR   KEGG; lmo:lmo1403; -.
DR   PATRIC; fig|169963.11.peg.1442; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q8Y789; -.
DR   BioCyc; LMON169963:LMO1403-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115110"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  98204 MW;  13D28DC9F230027A CRC64;
     MTEYTPMIKQ YLEIKDKYQD AFLFFRLGDF YEMFFEDALN ASQILEITLT GREGGTKEKI
     PMCGVPYHSA SGYIDTLIEK GYKVAICEQV EDPKTTKGMV KREVVQLISP GTVMDERGLK
     AKENNYIASL YCYEGKEYGF AYSDLSTGEL KSTVIEASED RLINELTTLS TRELIVSSSE
     KEVLSDVMKE QLGLTFSVHE EDTIPAENEK LVTRHMSLSE KRAIGKLLHY LKETQKRDLG
     HLQQAVHYET SNYMKMDYYS KRNLELAESI RGKGRQGTLL WLLDNTQTAM GGRMLKQWID
     RPLIDRKKII ERQNDVSELM AHFFERLELV ENLKNVYDLE RLAGRVAYGN VNARDLIQLR
     NSLYQIPRIR ATLLSMSSES LTELAEQLDP CEELTEKLEE AIMDSAPISI REGGIIKDGY
     NSQLDTYRDA SRNGKTWIAE LERKERELTG IKTLKVGFNR VFGYYIEVTR ANTHLLPEGR
     YERKQTLTNA ERYITPELKE KEKLILDAEE KSMELEYQLF SEVREMVKDY IERLQKLAKS
     VSEIDCLQSF ADISEKNHFI RPTLSEDGSL HVKQGRHPVV EKVMGAQSYV ANDCDLDENR
     EILLITGPNM SGKSTYMRQV ALTAICAQVG CFVPAEEAIL PIFDQIFTRI GAADDLIAGQ
     STFMVEMLEA RNAIVHATKD SLILFDEIGR GTATYDGMAL AQAIIEYIHE NVHAKTLFST
     HYHELTDLEK ELRGLQNIHV SAVEENGKVV FLHKIKEGPA DKSYGIHVAE LAELPKSLIE
     RASRILEQLE NDDKKIIIAS VKQPEEVHEE VQLSMFPLEP EKKASSKETK LLKEIASMNI
     MQMTPMDAMN KLYELQSKIH