ID   MUTS_LISW6              Reviewed;         860 AA.
AC   A0AIK5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lwe1419;
OS   Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 /
OS   NCTC 11857 / SLCC 5334 / V8).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=386043;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8;
RX   PubMed=16936040; DOI=10.1128/jb.00758-06;
RA   Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S.,
RA   Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O.,
RA   Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.,
RA   Lampidis R., Kreft J., Goebel W., Chakraborty T.;
RT   "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT   genome reduction with Listeria innocua as compared to Listeria
RT   monocytogenes.";
RL   J. Bacteriol. 188:7405-7415(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM263198; CAK20837.1; -; Genomic_DNA.
DR   RefSeq; WP_011702215.1; NC_008555.1.
DR   AlphaFoldDB; A0AIK5; -.
DR   SMR; A0AIK5; -.
DR   STRING; 386043.lwe1419; -.
DR   EnsemblBacteria; CAK20837; CAK20837; lwe1419.
DR   GeneID; 61189295; -.
DR   KEGG; lwe:lwe1419; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000779; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008074"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  98356 MW;  BC6B6EB3F5CB6BC6 CRC64;
     MTEYTPMIKQ YLEIKDKYQD AFLFFRLGDF YEMFFEDALN ASQILEITLT GREGGTKEKI
     PMCGVPYHSA SGYIDTLIEK GYKVAICEQV EDPKTTKGMV KREVVQLISP GTVMDERGLK
     AKENNYIASL YCYEGKEYGF AYSDLSTGEL KSTVIEASED RLINELTTLS TRELIVSESE
     KTVLSDVMKE QLGLTFSVHE EDTIPSENEK LVTRHMSLSE KRAIGKLLHY LKETQKRDLG
     HLQQAVHYET SNYMKMDYYS KRNLELAESI RGKGRQGTLL WLLDNTQTAM GGRMLKQWID
     RPLIDRKKII ERQNDVSELM ANFFERLELV ENLKNVYDLE RLAGRVAYGN VNARDLIQLR
     NSLYQIPRIR ATLLSMNSKS LTELANQLDP CEQLTEKLEE AIMDSAPISI REGGIIKDGY
     NSQLDTYRDA SRNGKTWIAE LERKERELTG IKTMKVGFNR VFGYYIEVTR ANTHLLPEGR
     YERKQTLTNA ERYITPELKE KEKLILDAEE KSMELEYLLF TEVREMVKDY IERLQKLAKS
     VSEIDCLQSF ADISEKNHFI RPTLSEDGSL HVKQGRHPVV EKVMGAQSYV ANDCDLDENR
     EILLITGPNM SGKSTYMRQV ALTAICAQVG CFVPAEEATL PIFDQIFTRI GAADDLIAGQ
     STFMVEMLEA RNAIVHATKD SLILFDEIGR GTATYDGMAL AQAIIEYIHE NVHAKTLFST
     HYHELTDLEK ELRGLQNIHV SAVEENGKVV FLHKIKEGPA DKSYGIHVAE LAELPKSLIE
     RASRILEQLE NENKKIIITN EKQPEEIHEE VQLSMFPVEP EKKTSSKETK LIKEIASMNI
     MQMTPMDAMN KLYELQSKIH