ID   MUTS_LYSSC              Reviewed;         856 AA.
AC   B1HRG8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Bsph_1655;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000817; ACA39253.1; -; Genomic_DNA.
DR   RefSeq; WP_012293356.1; NC_010382.1.
DR   AlphaFoldDB; B1HRG8; -.
DR   SMR; B1HRG8; -.
DR   EnsemblBacteria; ACA39253; ACA39253; Bsph_1655.
DR   KEGG; lsp:Bsph_1655; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000117290"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  96090 MW;  F350D5ECD344291E CRC64;
     MTTYTPMMQQ YLQVKEDYKD AFLFFRLGDF YEMFFEDAIN ASQILEITLT SRDAGAKERI
     PMCGVPHHSA KNYIETLVQK GYKVAICEQT EDPKQAKGVV KREVVQLITP GTIMEGKTLE
     GKSNHFIGAA EQLDDTTFGY AYLDLSTGEA VASSIEGDGK ALLMQMQAYG IRELIVTDSL
     QLLLAEHAAN AAIVLSVEAD EMTMDKAASY VEAVPPALQI SCLRLLAYID KTQMRSLSHI
     QAFTFNEMKH YLRIDSSSKR NLELIQSIRG GDQKGTLLWL LDDTVTAMGG RKLKQWLHQP
     LATRSAIESR LAIVTDLLEE YFVRTELQTA LKQVYDLERL AGRVAFGNVG GRDLAQLRDS
     LRQVPAIQQQ LMGAGKETLQ QIGVALDTCT DVVELLAKAI TDNPPITIKE GDVIRDGYHG
     RLDELRYAAR NGKDWIAQLE QEERLKTGIK NLKIGYNRIF GYYIEITKSN IHLADLTRYE
     RKQTLANAER YITQELKEKE ALILNAEEES LALEYNLFVE IRDALKEFIP RVQALAASIS
     ELDVLLSFAS ISEKYRFTKP QFHNGRALEI IEGRHPVVEK MLNKQMYVPN DCVLEEQNNM
     MLITGPNMSG KSTYMRQVAL IVVMAQMGCY VPAEKAKLPI TDQIFTRIGA ADDLAAGQST
     FMVEMLESQH AIMHATKNSL MLFDEIGRGT STYDGMSLAQ SMMEYIHDKI GANTLFSTHY
     HELTALEKDL PRLQNVHVAA TEKNGMVVFL HKVKKGAADK SYGIHVAQLA QLPEEILARA
     RVLLENFEAG NEVVAEAQKI AEPPLQMSLF TEEEPMAPAE AEVLKKLEKV NILGTSPMQA
     MNILYELQQE LLNMKK