ID   MUTS_MACCJ              Reviewed;         846 AA.
AC   B9EBI4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MCCL_0888;
OS   Macrococcus caseolyticus (strain JCSC5402).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX   NCBI_TaxID=458233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC5402;
RX   PubMed=19074389; DOI=10.1128/jb.01058-08;
RA   Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT   "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT   reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL   J. Bacteriol. 191:1180-1190(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP009484; BAH17595.1; -; Genomic_DNA.
DR   RefSeq; WP_012656795.1; NC_011999.1.
DR   AlphaFoldDB; B9EBI4; -.
DR   SMR; B9EBI4; -.
DR   STRING; 458233.MCCL_0888; -.
DR   EnsemblBacteria; BAH17595; BAH17595; MCCL_0888.
DR   KEGG; mcl:MCCL_0888; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001383; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..846
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118687"
FT   BINDING         594..601
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   846 AA;  97162 MW;  E81E4829EF312B83 CRC64;
     MSKPTPMMTQ YLQMKEQYKD CILFFRLGDF YEMFYEDAEL TAKELEITLT RRDKKNNIPM
     CGVPHHSAKV YIERLIEKGY KVAIAEQMED PKQVKGMVKR EVVKIITPGT VMDDMISENE
     SNYIASIHHE EGFTLAYSDV STGELKVTQL NEDEMLNELS SVNPKEIITN IDLNEVLINK
     IKMITDVISR FEVNDTFKQA DGVDQSLQPA VNLLLSYIQY TQMRALAHID EAVYYEPVHY
     MRLDMYAKRN LELTESIRHK NKKGTLLSIF NQCKTPMGNR LVKEWIERPL LNRQEIEERH
     NGVELFNDNF ILRHQLREAL THVYDIERLA GRVQFGNVSA KDLVQLKYSL EQLPMIQSLL
     KEHDEVIRTL DNIDALQPLY DMLEASLLDE APTSIKDGGI FKDGFNNDVD ELRYASKNGK
     QWLNELQAKE RERTGVKSLK IGYNKVFGYY IEISKANLVN LDVDAFGYTR KQTLSNAERF
     ITEELKEKES LILGAEEKLM NLEYELFIQL RDFVKTFILN LKQQAKNIAV LDCLQNFSEV
     ATKHQYIKPI ISGTKVLNIE DARHPVVETV MERDQYVAND CKLDDHTFIY LITGPNMSGK
     STYMRQVALI SIMAQMGAFV PASYAEVPIF DQIFTRIGAA DDLVSGQSTF MVEMLEAKNA
     LQNATDNSLI IFDEIGRGTS TYDGLSLAQS MIEYVHNKIG AKTLFSTHYH ELVDLEQTLD
     GLNNIHVAAK EYNGELIFLH KVMPGAVEHS YGIHVAKLAQ LPAEIIERSS ELLDEFEHNE
     KVRKGDSNKI IQPSFNLFEI ENENTNKYNA NHEHDLIIQQ IKDISIDELT PIEALLKLQE
     IKSRIK