ID   MUTS_MAGMM              Reviewed;         868 AA.
AC   A0L7L5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mmc1_1449;
OS   Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Magnetococcales;
OC   Magnetococcaceae; Magnetococcus.
OX   NCBI_TaxID=156889;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1437 / JCM 17883 / MC-1;
RX   PubMed=19465526; DOI=10.1128/aem.02874-08;
RA   Schubbe S., Williams T.J., Xie G., Kiss H.E., Brettin T.S., Martinez D.,
RA   Ross C.A., Schuler D., Cox B.L., Nealson K.H., Bazylinski D.A.;
RT   "Complete genome sequence of the chemolithoautotrophic marine magnetotactic
RT   coccus strain MC-1.";
RL   Appl. Environ. Microbiol. 75:4835-4852(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000471; ABK43958.1; -; Genomic_DNA.
DR   RefSeq; WP_011713111.1; NC_008576.1.
DR   AlphaFoldDB; A0L7L5; -.
DR   SMR; A0L7L5; -.
DR   STRING; 156889.Mmc1_1449; -.
DR   PRIDE; A0L7L5; -.
DR   EnsemblBacteria; ABK43958; ABK43958; Mmc1_1449.
DR   KEGG; mgm:Mmc1_1449; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002586; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..868
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335175"
FT   BINDING         623..630
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   868 AA;  97431 MW;  BABE88B54ADE10BA CRC64;
     MSSPKQTPMI AQYLSIKAAH PETLLFFRMG DFYELFFDDA KQAAEALNIA LTSRGKSEGE
     PIPMAGIPVH ARQTYLNKLI EAGFKVAICE QMEPPGASKG PVRREVVRTV TPGTLTEESL
     LSPRENNYLV SYLPAAKRHP HALAALDLST GEFFALTLER EDQVAAELSR LEPAELLIPD
     NWEPEPWLKG WKRCLSRRGS WSFDGKEGAR VLLEHFQVTS LESFGVADSP PCLGVCGALL
     HYCRETQKEA LSHITGLSRL HQQEGMVLDE TCRRNLELNY NLKDGSRKSS LLGVMDRCIT
     PMGSRLLAQW INRPLQSLDA IATRQESVSW LRENLVAYQD LRERLRMVHD LERFLSRIAL
     RRASPRDLGG LRQTLQCLPQ LYAILTPADG HSLAVPSLLR ILADHFNGHE ALTKQLEQQL
     ADELPLNLKE GETIRLGFDQ TLDTLRSLSR DGKSYLTKLE VEEREKTGIP SLKIKYHRSF
     GYSMEVTKTH LDKVPPRYIQ RQTMTNGVRY VTEELKEYEE QLLTAEERML EREQLLFEAL
     AEQVARQAET LQASARAIAT LDVLANFAHI AEERNYCRPL LHEGAVIEIN QGRHPVVEQF
     SDTPFVANDI RLDNRQRTGL ITGPNMAGKS TLMRQVALIV LLAHTGACVP AGSAKIGRVD
     RIFTRVGASD DLAGGRSTFM VEMTETAHIL HHASERSLVI LDEIGRGTST YDGLSIAWAV
     AEHIHTQCQA RTLFATHYHE LTQLESQLDG VFNLTVEVKE WKDQILFLHT IVRGAADRSY
     GIHVAQLAGL PRAVTRRARE VLADLEEHAV HHPDSMGQGH APASQPYQLT LFEDAPPSPA
     LLELKRVDPD ELTPKEALEA LYRLKELL