ID   MUTS_MAGSA              Reviewed;         882 AA.
AC   Q2WAN4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=amb0287;
OS   Magnetospirillum magneticum (strain AMB-1 / ATCC 700264).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Magnetospirillum.
OX   NCBI_TaxID=342108;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AMB-1 / ATCC 700264;
RX   PubMed=16303747; DOI=10.1093/dnares/dsi002;
RA   Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.;
RT   "Complete genome sequence of the facultative anaerobic magnetotactic
RT   bacterium Magnetospirillum sp. strain AMB-1.";
RL   DNA Res. 12:157-166(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE49091.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP007255; BAE49091.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q2WAN4; -.
DR   SMR; Q2WAN4; -.
DR   STRING; 342108.amb0287; -.
DR   EnsemblBacteria; BAE49091; BAE49091; amb0287.
DR   KEGG; mag:amb0287; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000007058; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335176"
FT   BINDING         634..641
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  95095 MW;  C8674B600EE87058 CRC64;
     MTVETPPIPD DATPMMAQYL AIKRAHPDCL LFYRMGDFYE LFFDDAVKAS AALDIALTKR
     GKHAGEDIAM CGVPVRAYEA YLAKLVRSGF KVAIGEQMED PAEAKKRGSK SVVARDVVRV
     ITAGTLTEDT LLDARSHNYL AAVAEAQGTL GLAWVDVSTG DFAMQAIAPK TLAAALARLS
     PGELLVSDRL LGAADFFDVW ADWKNVLSPL PTARFDSENS RRRLEALYGV GALDGFGAFS
     RAELAAGGAL VDYVELTQKG KLPRLSLPKR LAEGAVMEID AATRRNLELA ETLSGERRGS
     LLATIDRTVT GAGARLLAAQ LAAPLTDPHA IEWRLDMVGF FVEHESVRAQ LRETLKRCPD
     VERALSRLSL GRGGPRDLAN VRDALAEIPA LRMLVTQSHL DTPPGINQCA RELGEHSALV
     DRLQRALAPD LPLNARDGGF IAQGYHEGLD ELKGLKTESN GLMMRLEKRY QDETGIASLK
     IRHNNIIGHH IEVPSKQADR LGEGYIHRQT MANAARYTTT ELIELAGKIT GAADRALALE
     MELLADLIGE VTARAAEIAL AAAALAGLDC ASALGEMASS ARWSRPRVDD STAFDIRGAR
     HPVVEAALEA ARSGPFVAND CDLADSQRLW LVTGPNMAGK STFLRQNAVI AILAQMGSFV
     PAESVHMGVV DRLFSRVGAA DDLARGRSTF MVEMVETAAI LNQAGPRALV ILDEIGRGTA
     TFDGLSIAWA VVEHLHEVNR CRALFATHYH ELTRLTSRLA ALSCHMMRVK EWQGDVVFLH
     EVGAGAADRS YGIHVARLAG LPPAVVGRAE EVLGILEKSD QASGMARLAD DLPLFAALAK
     PRPAATALPQ ASPLEEALKA VNPDDLTARQ ALDLVYELKR LL