ID   MUTS_MANSM              Reviewed;         861 AA.
AC   Q65QA9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MS2244;
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE016827; AAU38851.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q65QA9; -.
DR   SMR; Q65QA9; -.
DR   STRING; 221988.MS2244; -.
DR   EnsemblBacteria; AAU38851; AAU38851; MS2244.
DR   KEGG; msu:MS2244; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224382"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  95942 MW;  D6457028869F8F71 CRC64;
     MNVMENLEQH TPMMRQYLAL KAENPDILLF YRMGDFYELF YDDAKKAAAL LDISLTKRGQ
     SAGQPIPMAG VPYHAVEGYL AKLVQLGESV AICEQIGDPA LSKGPVERKI VRIVTPGTVS
     DENLLPERQD NLIVAVYQEK DKFGLATLDM TSGRFQISEP ENAESLKAEL QRLAPAELLY
     CEDFADMQLI EHYKGLRRRP IWEFELSTAV QLLNRQFGTK DLRGFGVEKA ILGLCAAGCL
     LQYAKETQRT ALPHIQSITL IQNNENIQLD AATRRNLELT QNLAGGTENT LASVLDKCVT
     PMGSRLLKRW IHQPIRHIQK LRQRQQIISE IIQLDLIGEL QPYLQQVGDM ERILARVALR
     TARPRDLTRL RTALEQIPTI KDILKNSPKF TALFQQIGDF DELFALLQQA IIDNPPLLIR
     DGGVIAEGYN AELDEWRALS DGATKYLEDL EIRERESTGI DTLKVGFNAV HGYYIQISQG
     QAHKAPIHYV RRQTLKNAER FIIPELKTYE DKVLKAKGAS LALEKQLYDA LFDRLLPHLG
     ALQLASLTLS ALDVLTNLAE RAETLNYVAP DFSDEIGVKI ENGRHPVVEQ VLKEPFIANP
     VDLNQQRHLL IITGPNMGGK STYMRQTALI TLMAYIGSFV PAESALIGPI DRIFTRIGAS
     DDLASGRSTF MVEMTEMANI LHQAGANSLV LIDEIGRGTS TYDGLSLAWA CAEWLAKKLR
     SLTLFATHYF ELTVLPEQLA GTANVHLDAL EHGDSIAFMH AVQDGAASKS YGLAVAALAG
     VPKNVVKLAK QKLANLEKLS QQSADQKLQD LRTINQNQGE LNLMEEEDGK NAALEMLAQL
     DPDDLSPKQA LAYLYQLKKL L