ID   MUTS_MARMM              Reviewed;         897 AA.
AC   Q0AK91;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mmar10_3021;
OS   Maricaulis maris (strain MCS10).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Maricaulales; Maricaulaceae;
OC   Maricaulis.
OX   NCBI_TaxID=394221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MCS10;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P.,
RA   Stephens C., Richardson P.;
RT   "Complete sequence of Maricaulis maris MCS10.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000449; ABI67302.1; -; Genomic_DNA.
DR   RefSeq; WP_011644946.1; NC_008347.1.
DR   AlphaFoldDB; Q0AK91; -.
DR   SMR; Q0AK91; -.
DR   STRING; 394221.Mmar10_3021; -.
DR   EnsemblBacteria; ABI67302; ABI67302; Mmar10_3021.
DR   KEGG; mmr:Mmar10_3021; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001964; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..897
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335177"
FT   BINDING         654..661
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   897 AA;  96338 MW;  DECF2A949E60BE39 CRC64;
     MNAMSTLPVP RDRTFPSSEG ATPMMQQFLE LRAQAPADAL LFYRMGDFYE LFFDDAVRAS
     AALDIALTKR GEHQGEPISM CGVPAATAEA YLARLIKAGF KVAVGEQMED PKTAKARGGS
     KAVVRRAITR VVTPGTLTED SLLDPRVSNR IAALAQLVTG EAALAWADVS TGDFRVSPVA
     TENLAAEIAA MSPAELLVEE RGFAEAAMLA PRSTLTPLPK AKFDPSSAER QLKDQFRVQE
     LTAFGNFTKA ECAALGALLD YLSLSQAGAP AKLAPPRQVA AGACLAIDPA TRASLEIERT
     LSGSRQGSLL DAIDRTVTAP GARKLAERLA RPLTNVAEIE ARLDAIAWFE RARPERRDLR
     DRLRQAGDAE RALSRLLLGR GGPRDLKSLA AALQEGEIIA SRLLDRTLDT PPTLISEGLE
     ALVLGDKPEL AELIAELERA IVDEPPLLAR DGGFIAEGWQ VELDELRQLR DASRRVVAGL
     QQTYAEAVGV SALKIKHNNV LGYFVEVTAK HGDALMGDDR FIHRQTMANA IRFSTTELAE
     LEAKIASAGD RALAMEIDAF AGLRDRVEAQ ADLIRGAARA LAEFDVAASL AEWAEDSEAA
     RPVMSQDSVF HIEGGRHPVV ERALAKAGDG RFTPNDCHLD GAGEEAKRLT FVTGPNMAGK
     STFLRQNALI LMLAQAGCYV PARAARIGVA DRLYSRVGAA DDLARGRSTF MAEMIETAAI
     LNQATARSFV ILDEIGRGTA TFDGLSIAWA AAEHLHAVNG CRALFATHYH ELTRLADDLD
     AAGNVSLKAR EWKGELVFLH EVGSGAADRS YGIEVARRAG LPRVSVKRAQ AILARLEADG
     APAAALTDLP LFALSEPEPE PVISEVETRL GEIDPDALSP REALEVLYAL KAMTKKT