ID   MUTS_MARMS              Reviewed;         883 AA.
AC   A6W1Q6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mmwyl1_3734;
OS   Marinomonas sp. (strain MWYL1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=400668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWYL1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y.,
RA   Richardson P.;
RT   "Complete sequence of Marinomonas sp. MWYL1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000749; ABR72635.1; -; Genomic_DNA.
DR   RefSeq; WP_012071400.1; NC_009654.1.
DR   AlphaFoldDB; A6W1Q6; -.
DR   SMR; A6W1Q6; -.
DR   STRING; 400668.Mmwyl1_3734; -.
DR   EnsemblBacteria; ABR72635; ABR72635; Mmwyl1_3734.
DR   KEGG; mmw:Mmwyl1_3734; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..883
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335178"
FT   BINDING         619..626
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   883 AA;  97973 MW;  E9453566AC25D870 CRC64;
     MSKTPADNHT PMMRQYFGLK SQHPNQLLFY RMGDFYELFY DDAKRASRLL DITLTARGHS
     GGIPIPMAGI PYHAAENYIA RLVRMGESVV VAEQTGDPAT SKGPVERQIA RIVTPGTISD
     EAFLEEKREN LLLSLAHQSR KGLDIFGFSY LDMASGRFCL FEVDGHEALS SELQRLSPRE
     ILISEDFPAR ATLKLEKGIS ELGPWHFDYE SSYRQLIQQF STKDLSGFGC EAMTAAIASA
     GALLQYAKDT QRSALPHIQS IMVEHKDDSV LIDGATRRNL EIDINLTGGT SNTLVEVLDK
     CSTPMGSRLL KRWLHTPIRD LNEIQARQQV VAELQQNQSY NAFEAPLKKV GDLERILSRV
     ALRSARPRDL LRLRFALEAA PEINGLLANA TSERLQELNL RILAQPIITE TLAKALVENP
     PSVVRDGGIF AKGYDEELDE LLALSTNATD FLAEMERSEK ARTGISSLKV GFNRVHGYYI
     EISRLHSDQA PVEYIRRQTL KNAERFITPE LKAFEDKALS AKSKSLAREK ELYEALLEQL
     NEILGELQTT SQALAQLDVL NNFAERANAL SFTCPELHNR GGIQIVGGRH PVVESVISEP
     FVPNDLDLND KRSLLMITGP NMGGKSTYMR QIALITLLAH TGCFVPAESA SISVVDRIFT
     RMGSSDDLAG GRSTFMVEMT ETANILNNAS KNSLVLMDEV GRGTSTFDGL SLAWAAVDYL
     ANKLKCYVLF ATHYFELTTL ADQLENAANV HLTATEYEDE IVFLHKVHEG PASQSYGLQV
     AQLAGVPRDV IGHAKQKLKE LEVVTGIDLD TKTIETKANS SSIKAKTKEH LVKESKNGYQ
     PQQVDMFAQA EQNALKNALE ELDLDNMTPL EAISALYKLK SQL