ID   MUTS_MARN8              Reviewed;         874 AA.
AC   A1U2E8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Maqu_2087;
OS   Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter
OS   aquaeolei).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Marinobacteraceae; Marinobacter.
OX   NCBI_TaxID=351348;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700491 / DSM 11845 / VT8;
RX   PubMed=21335390; DOI=10.1128/aem.01866-10;
RA   Singer E., Webb E.A., Nelson W.C., Heidelberg J.F., Ivanova N., Pati A.,
RA   Edwards K.J.;
RT   "Genomic potential of Marinobacter aquaeolei, a biogeochemical
RT   'opportunitroph'.";
RL   Appl. Environ. Microbiol. 77:2763-2771(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000514; ABM19167.1; -; Genomic_DNA.
DR   RefSeq; WP_011785559.1; NC_008740.1.
DR   AlphaFoldDB; A1U2E8; -.
DR   SMR; A1U2E8; -.
DR   STRING; 351348.Maqu_2087; -.
DR   EnsemblBacteria; ABM19167; ABM19167; Maqu_2087.
DR   KEGG; maq:Maqu_2087; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000998; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..874
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008075"
FT   REGION          799..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   874 AA;  97128 MW;  37CDC7B20DF09B7E CRC64;
     MTDLSKHTPM MQQYLKIKGE HPNEMVFYRM GDFYELFYDD AKKAAELLDI TLTARGQSGG
     NPIPMAGVPF HSAEGYIARM VRAGQSIAIC EQIGDPATSK GPVERKVVRI VTPGTLSDEA
     FLEDRRDNLL AAIYHHKEQF GFASLDISSG RFAVSELESL EALQGELQRL RPAEILISED
     FPYTDILEGF TGVRRQGPWL FESDTALRVI TQQLQVRDLT GFGCEDLTLA VCAAGCLLQY
     AKETQRTALP HIRKLTRERR EDAVILDAAS RRNLEIDTNL MGGQQHTLAW VMDRTATAMG
     ARELRRWLNR PLRDVERVRQ RQQAVSALLD GFHYEPVHDL LKRVGDIERI LARVALRSAR
     PRDLARLRDA FHALPELQEA LKPVNSHHVV KLATVIGEYP ELADLLERAI IDNPPVVIRD
     GGVIAEGFDE ELDELRNISE NAGQYLLDVE TRERERTGIS TLKVGYNRVH GYYIEISRAQ
     SDQAPVDYIR RQTLKNAERF ITPELKEFED KALSAKSRAL AREKGLYDDV LETVAEQLAP
     LQDAAQALAE LDVLSNFAER ATSLRFTAPE FTDQPGFDVE EGRHPVVEQL LDEPFVPNNL
     LMDTKRRMLV ITGPNMGGKS TYMRQAALIA LLAYTGSFVP ANRAVLGPVD RIFTRMGSSD
     DIAGGRSTFM VEMTETANIL HNATEHSLVL MDEVGRGTST FDGLSLAWAT AEHLAKNIRC
     YTLFATHYFE LTQLADDLEH AVNVHLTATE HDDSIVFLHN VHDGPASQSY GLQVAKLAGV
     PQDVIRNAKT QLAHLEGLEA GSTPSPAPVS VNEPKPAAPT ATKAASVEAV YQGDMFAMAE
     PSVVEQALEK LDLDGITPRD ALNQLYELKG LLAK