ID   MUTS_METAC              Reviewed;         900 AA.
AC   Q8TTB4;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MA_0523;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010299; AAM03967.1; -; Genomic_DNA.
DR   RefSeq; WP_011020572.1; NC_003552.1.
DR   AlphaFoldDB; Q8TTB4; -.
DR   SMR; Q8TTB4; -.
DR   STRING; 188937.MA_0523; -.
DR   EnsemblBacteria; AAM03967; AAM03967; MA_0523.
DR   GeneID; 1472415; -.
DR   KEGG; mac:MA_0523; -.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   InParanoid; Q8TTB4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 1024at2157; -.
DR   PhylomeDB; Q8TTB4; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..900
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115177"
FT   BINDING         637..644
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   900 AA;  100646 MW;  F330B8F293A87831 CRC64;
     MTEIMTPAMR QYYEAKQAYP DTLIFFRMGD FYESFGEDAK TIAKELEITL TARGKDRTGE
     RMPLAGIPYH AIDTYLPRLI NKGYKVAICE QLEDPKKAKG VVKRGVVRVV TPGTAIDSSM
     FSDASNNYLM AVAGREGGKS GKNGEKEMEF GISFLDISTG EFLTTQFTDS ENFDKLLSEL
     ARMHPAECIL PPSLYGNSEL TGKLREHTIV QEFAPEVFGT EEAGEKLKTH FGVATLEGMG
     CQKLEFAVYS AWAALEYAKT TQMRDLTHIN TLRTYSNTEF MILDSITLRN LEIVKNVRDE
     GDENSLYRTL NCTRTPMGNR TLKKWLLKPL LSVEKINPRL DAIEELAEDS LLRYDIRDWL
     SDVRDIERLV GRIVYGNASA RDLVALKKSL GVVPSLRDSL LEKARFEMLK EIAEGLASFS
     ELEELAEMIE IAIMDEPPVS VREGGMIKSG YSPELDELRD ISSNSKQWIA AFQQKERERS
     GIKSLKVGYN KVFGYYIEVT HANSSQVPED YIRKQTMANA ERFFTPELKE KESLILTANE
     KAVALEYEIF AEITRTLSAR SRELQETAER IGTLDVLASL AEATENNNYT RPQLTEDCKI
     LIRDGRHPVV ESTVSGGFVP NDTEMDCKEN QFLLVTGPNM AGKSTYMRQT ALIAIMAQVG
     SFVPASYASV GIIDQVFTRI GAFDDLASGQ STFMVEMVEL ANILNNASPK SLVLLDEIGR
     GTSTYDGYSI AKAVVEFLHN RGKVGIRALF ATHYHQLTAL EEKLKRVKNY HIAVKEDGHE
     LVFLRKIVPG ATDRSYGIHV ARLAGVPEKV IERANEILKE LERENVLEEA EDGENGKKKK
     SKATARYTQM LLFDPGSGSR SSEKAKGLSP VEAALKKVNP DEMTPIEALN KLHELKKLLG