ID   MUTS_METBF              Reviewed;         900 AA.
AC   Q46CE2;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mbar_A1495;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000099; AAZ70450.1; -; Genomic_DNA.
DR   RefSeq; WP_011306496.1; NC_007355.1.
DR   AlphaFoldDB; Q46CE2; -.
DR   SMR; Q46CE2; -.
DR   STRING; 269797.Mbar_A1495; -.
DR   EnsemblBacteria; AAZ70450; AAZ70450; Mbar_A1495.
DR   GeneID; 3627681; -.
DR   KEGG; mba:Mbar_A1495; -.
DR   eggNOG; arCOG02897; Archaea.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 1024at2157; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..900
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224424"
FT   BINDING         637..644
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   900 AA;  101117 MW;  E120CDF22D344669 CRC64;
     MTKMMTPAMC QYYEAKQAYP DTLIFFRMGD FYESFGEDAK TIAKELEITL TARGKDKSGE
     RMPLAGIPYH AIDTYLPRLI NKGYKVAICE QLEDPKKAKG IVKRGVVRVV TPGTAIDSSM
     FSDASNNYLM AVAGREIGKP GKNAENEFEI GVSFLDISTG EFLTTQFRDS ENFEKLLSEL
     ARMRPSECIL PSSLYENPAL AERLRAQTIV QEFAPDISGA KEAGERLKNH FRVATLEGMG
     CENLDFAVYS AWAALEYAQT TQMRELTHIN TLRTYSNSEF MILDSVTLRN LEIVKNVRDE
     GDENSLYRIL NHTKTPMGSR ALKKWLLKPL LSVEKINYRL DAVEELTAKP LLRYDLRNWL
     SDVRDIERLV GRVVYGNSNA RDLVALKKSL EALPPVRDSL LENIESTILN DIAVGLASFS
     ELENLAEMID RAIVDEPPIS VREGGMIKSG YNAELDELKD IASNSRQWIA NFQQKERERS
     GIKSLKVGYN KIFGYYIEVT NANSSQVPED YIRKQTMANA ERFFTPELKE KESLILTANE
     KAIALEYEIF TEILQTLSAH SRELQETAER IGTLDVLTDL AEVAENNNYI RPQLTDDCKI
     LIRDGRHPVV ENTVHGGFVP NDTEMDCKEN QFLLVTGPNM AGKSTYMRQT ALIAIMAQVG
     SFVPASYASI GIIDQVFTRI GAFDDLASGQ STFMVEMVEL ANILNNASPR SLVLLDEIGR
     GTSTYDGYSI AKAVVEFLHN RGKVGVRALF ATHYHQLTAL EEKLKRVKNY HVAVKEEGHE
     LVFLRKIVPG ATDRSYGIQV ARLAGVPEKV IERANEILKE LERENVLEEV EDSKNGKKRK
     SKATARYTQM MLFDPGDSGG NTAKVNRPSP VETVLKKLNV DEMTPIEALN KLHELKRLLN