ID   MUTS_METBU              Reviewed;         887 AA.
AC   Q12VC9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mbur_1704;
OS   Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS   ACE-M).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M;
RX   PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA   Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA   De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA   Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA   Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA   Cavicchioli R.;
RT   "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT   burtonii: the role of genome evolution in cold adaptation.";
RL   ISME J. 3:1012-1035(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000300; ABE52597.1; -; Genomic_DNA.
DR   RefSeq; WP_011499740.1; NC_007955.1.
DR   AlphaFoldDB; Q12VC9; -.
DR   SMR; Q12VC9; -.
DR   STRING; 259564.Mbur_1704; -.
DR   EnsemblBacteria; ABE52597; ABE52597; Mbur_1704.
DR   GeneID; 3997378; -.
DR   KEGG; mbu:Mbur_1704; -.
DR   HOGENOM; CLU_002472_1_3_2; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 1024at2157; -.
DR   Proteomes; UP000001979; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..887
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335245"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   887 AA;  98569 MW;  93A8CC207C15AE42 CRC64;
     MIKLTPAMKQ YYDAKKQHSD ALIFFRMGDF YESFGEDAKI IAKELEITLT TRGKDIEGEK
     MPLAGIPYHA LDNYLPRLIK KGYKVAICEQ LEDPKKAKGI IKRGVVRVVT PGTAIDTSMF
     TDPSNNYLMS ISGGDGDYGV SFLDVSTGEF LTTQFADKSP YDRIASEAAR MRPSECIISR
     TMFSDERLVE RLKELNVLVQ GFKDEAFDVD SSRKLLERHF NVSTLEGMGC AGLPYATSSA
     GAALDYALTT QMRELGHVSE LSTYSDSEFM MLDSITLRNL EIVKNVRGEG NDTSILKVLD
     DTNTPMGGRL LQKWLLKPLI NVDSIDHRLD ALECLANDTM LRFDVRSHLS FVKDIERLIG
     RVVYGNSNAR DLIALKRSLG SVPQIVESMG DDPGCEMLIN IRDGLLGFEQ LENIVKLIDD
     AIVDEPPVSV REGGMIRSGY NEKLDELKGM STGGKTWIAS FQQKERDRTG IKSLKVGYNR
     VFGYYIEITK SNIAQIPDDY IRKQTMRNAE RFYTPELKEW EDVILSADEK ITALENELFT
     EITSRIASHA SDLQRIAVLI GQLDCTASLA EVAVNNNFVR PNITSDCKIL IREGRHPVVE
     KTVRGGFVPN DTEMDCVDEQ FLLITGPNMA GKSTYMRQVS LIVIMAQAGS FVPASHASIG
     IVDRVFTRVG AFDDLASGQS TFMVEMVELA NILNNATPKS LVLLDEIGRG TSTYDGYSIA
     KAVVEYIHNK GRVGVRSLFA THYHQLTNIS SSLKRVKNYH IAVKEDGDDL VFLRKIVPGA
     TDKSYGIHVA RLAGVPHKVT QRAKEVLQDI EDESVISKES DSKRGRKKKS AQYTQLMLFD
     PEGSSAPVAE PDPVVEELKE LDVNSMTPIE ALNKLSELQK KAGKGGK