ID   MUTS_METFK              Reviewed;         884 AA.
AC   Q1H2P1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS1 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mfla_0834;
GN   and
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mfla_0978;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000284; ABE49102.1; -; Genomic_DNA.
DR   EMBL; CP000284; ABE49246.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1H2P1; -.
DR   SMR; Q1H2P1; -.
DR   STRING; 265072.Mfla_0834; -.
DR   EnsemblBacteria; ABE49102; ABE49102; Mfla_0834.
DR   EnsemblBacteria; ABE49246; ABE49246; Mfla_0978.
DR   KEGG; mfa:Mfla_0834; -.
DR   KEGG; mfa:Mfla_0978; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..884
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335181"
FT   BINDING         643..650
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   884 AA;  97850 MW;  9F71C3A2A58904F8 CRC64;
     MHGEHDRGGV IIKVCDDVLA LAGKHERAIN LTKLDNTLEQ HTPMMRQYLG IKAQYPDMLV
     FYRMGDFYEL FHDDAEKASR LLGITLTKRG SSNGEPIRMA GVPYHAAEQY LAKLAKLGEA
     VAICEQVGDP AKSKGPVERQ VTRILTPGTL TDAALLDDTR DNLLLAIAHG EGVLGLARIN
     LASGRFILSE ITPGLLAQEL ERISPAEILY PDDFYHMALE QVKCPKKRLA PWQFDLDSSI
     QTLTKQFSTY DLDGFGCAHM LAAIMAAGAL LDYVKHTQRT SLPHIQSLMV EQGSQFIQLD
     AATRRNLEID QTLRGESSPT LYSLLNTTVT AMGARLLRSW LHHPLQHQAD IQARLQAVKV
     LQAQYDGLRP LLRNVGDIER MAARVALKTA RPRDLSGLRD SLQQLPALQR VLRPEDSALL
     HSLQQQLDVP QAALDMLIAA IKDEPAAVLR EGGVIADGFD AELDELRAIQ SNCGEFLLQF
     EAQERERSGI SNLKVEYNSV HGFYIEISRA QSENVPAEYR RRQTLKNVER YITPELKTFE
     DKVLSANERA LAREKFLFDE LLGNLQPALA AWQRNAEAVA QLDVLATFAE RADVLKYVAP
     QFSSEAGLDI VDGRHPVVEQ LAQPFIANSV SLSPYRQLLL ITGPNMGGKS TYMRQTALIV
     LLAHCGCFVP AKSARIGPID RIFTRIGASD DLAGGRSTFM VEMTETANIL HNATERSLVL
     LDEIGRGTST FDGLSLAWAV ARQLLEKNRS YTLFATHYFE LTRISEEFKH AANVHLDAVE
     HGDGIVFLHN VEEGPASQSY GLQVAQLAGI PRTVVNAAKR KLVQLEQSQV MQQSLAGQGD
     MFVAANVEPE PATHPVVSEL ESIDPDSLTP RQALDVLYKL KKLI