ID   MUTS_METMA              Reviewed;         900 AA.
AC   Q8PWA7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MM_1683;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE008384; AAM31379.1; -; Genomic_DNA.
DR   RefSeq; WP_011033625.1; NC_003901.1.
DR   AlphaFoldDB; Q8PWA7; -.
DR   SMR; Q8PWA7; -.
DR   STRING; 192952.MM_1683; -.
DR   EnsemblBacteria; AAM31379; AAM31379; MM_1683.
DR   GeneID; 44088679; -.
DR   KEGG; mma:MM_1683; -.
DR   PATRIC; fig|192952.21.peg.1950; -.
DR   eggNOG; arCOG02897; Archaea.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..900
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115178"
FT   BINDING         637..644
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   900 AA;  100504 MW;  B062AE23C7FB1D15 CRC64;
     MTEMMTPAMR QYYEAKQAYP DTLIFFRMGD FYESFGEDAK TIAKELEITL TARGKDRSGE
     RMPLAGIPYH AIDTYLPRLI NKGYKVAICE QLEDPKQAKG VVKRGVVRVV TPGTAIDSSM
     FPDASNNYLM AVAGKEVGKT GKSGEKEMEF GLSFLDISTG EFLTTQFTDS GSFDKLLSEL
     ARMKPAECIL PPTLYGNSVL VDRLREQTIV QEFAPEISGI EEAGEKLKIH FRVSTLEGMG
     CEKLEFGVYS AWSALEYAKT TQMRDLAHIN TLRTYSNTEF MVLDSVTLRN LEIVKNVRDE
     GDHNSLYRTL SFTKTPMGSR ILKKWLLKPL LSVEQINHRL DAVEELAGNP LLRYDIRDWL
     SEVRDIERLV GRIVYGNANA RDLVALKKSL DAVPSIRDCL LEKAGAEMLK GIAEGLASFS
     EIEELAKMIG NAIVEEPPVS VREGGMIKSG FSEELDELRD ISSNSKQWIA AFQQKEKDRT
     GIKSLKIGYN KVFGYYIEVT NANSSQVPDD YIRKQTMANA ERFFTPELKE KESLILTAND
     KAVALEYEIF TEITETLSAH SKELQETAER IGVLDVLADL AEVAENNNYT RPQLTEDCKI
     LIRDGRHPVV ESTVSGGFVP NDTEMDCKEN QFLLVTGPNM AGKSTYMRQT ALIAIMAQAG
     SFVPASYASI GVIDQVFTRI GAFDDLASGQ STFMVEMVEL ANILNNASPK SLVLLDEIGR
     GTSTYDGYSI AKAVVEFLHN RGKVGIRALF ATHYHQLTSL EEKLKRVKNY HIAVKEEGHE
     LVFLRKIVPG ATDRSYGIHV ARLAGVPEKV IERANEILRE LERESVLEES EDCENGKKRK
     GKATTRYTQM LLFDPGSRSG NSEVKRGLSP VEAALKKMNV DEMTPIEAMN KLHELKKLLG