ID   MUTS_METPP              Reviewed;         870 AA.
AC   A2SJQ7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mpe_A2842;
OS   Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Methylibium.
OX   NCBI_TaxID=420662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1232 / LMG 22953 / PM1;
RX   PubMed=17158667; DOI=10.1128/jb.01259-06;
RA   Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA   Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA   Hristova K.R.;
RT   "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT   proteobacterium Methylibium petroleiphilum PM1.";
RL   J. Bacteriol. 189:1931-1945(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000555; ABM95796.1; -; Genomic_DNA.
DR   RefSeq; WP_011830425.1; NC_008825.1.
DR   AlphaFoldDB; A2SJQ7; -.
DR   SMR; A2SJQ7; -.
DR   STRING; 420662.Mpe_A2842; -.
DR   EnsemblBacteria; ABM95796; ABM95796; Mpe_A2842.
DR   KEGG; mpt:Mpe_A2842; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000366; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335180"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  93941 MW;  5C30A7E96BF68213 CRC64;
     MSADPARAES GHTPMMQQYL RIKAEHPDTL VLYRMGDFYE LFFDDARKAH RLLDITLTSR
     GQSAGEPVVM AGVPVHALEN YLGKLVKLGE SVAIAEQVGD VATAKGPVER KVVRVVTPGT
     VTDTELLSER VDTLLLAVTR QRASYGLAWL GLSSGTLGLS ECGERELAGW LARLGPAEVL
     VDDRDDAALT AALSTTRTAL TRRPAWQFDT ALGRRKLCEQ LRVASLAGFN AEDVSAAHAA
     AAALLSYAEH TQGRALAHVG SLAVERASDL LELPPATHRN LELTQTLRGE DAPTLLSLLD
     VCRTGMGSRA LRHWLTHPAR VRTAARARHE AIGALMERGG EVLREALRGV SDVERITARI
     ALRQVRPREL TGLRATLLAL PALRDGVPRD SALLADLAQQ LSPPPEIADL LQRAIADEPA
     VLLRDGGVIA TGHDAALDEL RGIAQNCEAF LLDLEARERN RTGIANLRVQ FNRVHGFYIE
     VTQGQVDKVP ADYQRRQTLK NAERYITPEL KAFEDKALSA QERALAREKL LYDGVLDALQ
     PQLAALGAVA RALASLDALA ALAERAAVLN WCCPEFVSQP CIEIEQGRHP VVEARLAETG
     GGSFIPNDCR LDANRRMLVI TGPNMGGKST FMRQVALVVL LAAMGSYVPA AACRLGPVDA
     IHTRIGAADD LANAQSTFML EMTEAAAIVH GATEHSLVLM DEIGRGTSTF DGLALAGAIA
     SQLHDRNRAF TLFATHYFEL TAFPEKHPRA LNVHVSAAES HTGHGDDIVF LHEIQPGPAS
     RSYGVQVARL AGMPAPLLRQ ARATLEALEA QQAASASQID LFAAPPPSPP REATELERAL
     AGVEPDTLTP REALDALYRL KSLHERSKEN