ID   MUTS_METTP              Reviewed;         857 AA.
AC   A0B976;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mthe_1477;
OS   Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS   PT) (Methanosaeta thermophila).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=349307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT   "Complete sequence of Methanosaeta thermophila PT.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000477; ABK15250.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0B976; -.
DR   SMR; A0B976; -.
DR   STRING; 349307.Mthe_1477; -.
DR   EnsemblBacteria; ABK15250; ABK15250; Mthe_1477.
DR   KEGG; mtp:Mthe_1477; -.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000674; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008076"
FT   BINDING         603..610
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  95811 MW;  3FE1B34EE956F4D6 CRC64;
     MMVRLSPLME QYSRIKQQCP DALLLFRVGD FYETFGEDAI TTSRTLNITL TSRQKDDEGN
     RIPLAGIPYH SLDVYLSRLV NAGHKVAICE QVEDPKQAKG IVRREITRIV TPGTVIEPAL
     LQERSNNYLA AVLLENGLAG LSLLDLSTGD FIASEVPVER LGSELARFSP AECLAPPGVS
     LEGMKFQNLD AELFSLNEAS ESGGILGDLH KRSPLCARAA CAILSYLRET RIQSVDHIKP
     IRMISSSEYM LLDEITLRNL EIFRNLRDGS RSGTLMEILD ETVTPMGSRT LARWLQMPSM
     SLEVIRRRQD AIEEMVRRAV IREEISELLD GLSDLERIIG RVSLGNAGPK DLVALRSSLR
     RIPEIAHAMS ALESEYLVEI RKRLDASELD DLVVLLERAL SDDPPTSPRD GGVIRDGYSP
     ELDEIRSALR NGRSWIAELE SSERKRTGIK SLKVGYNNVF GYYIEVTKPN LSMVPDDYIR
     KQTLSNAERF VTRELKEVES RVLSAQERSS ALEYEVFLDL RGQVASRTRS VQEVAAAIGE
     LDTILGLTRA ALMGAMVRPV VDAGREVILR DSRHPVLDRV MKGGFVPNDL TMDESSWFMI
     LTGPNMAGKS TFMRQVALIA IMAQIGSFVP ASYAKIGLID RIFTRVGARD DLVSGRSTFM
     VEMSELANIL VSATKDSLIL LDEIGRGTST FDGLSIAWAV SEYIHSRIKA KTIFATHYHQ
     LTQLNLPGIV NYSMAVKEEG RSITFLRTVV PGATNKSYGI HVARLAGVPE HVIRRAEELL
     DIIEEQAAIE IRKCRSKERP KRYTQLIFFN QPESIDNDIL EEIKNLEPEK ITPLQALNLL
     VEYRRRLGCK DAKDTHT