ID   MUTS_MICAN              Reviewed;         882 AA.
AC   B0JFY0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MAE_21630;
OS   Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Microcystaceae; Microcystis.
OX   NCBI_TaxID=449447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-843 / IAM M-247;
RX   PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA   Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA   Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA   Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA   Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT   "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT   Microcystis aeruginosa NIES-843.";
RL   DNA Res. 14:247-256(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP009552; BAG01985.1; -; Genomic_DNA.
DR   RefSeq; WP_012265372.1; NC_010296.1.
DR   AlphaFoldDB; B0JFY0; -.
DR   SMR; B0JFY0; -.
DR   STRING; 449447.MAE_21630; -.
DR   PaxDb; B0JFY0; -.
DR   EnsemblBacteria; BAG01985; BAG01985; MAE_21630.
DR   KEGG; mar:MAE_21630; -.
DR   PATRIC; fig|449447.4.peg.1977; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; MAER449447:MAE_RS09430-MON; -.
DR   Proteomes; UP000001510; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335182"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  98178 MW;  0E2BD2B9E19889F1 CRC64;
     MTLPSDFPLE PPATNKDPHR DYRGLDRSKL TPMYQHYVEV KETYPNALLL YRVGDFFECF
     FQDAVIISRE LELVLTSKEG GKGIGRVAMT GVPHHALERY SRLLVEKGYA VAICDQVEDS
     TEAAAEKRLV ERAITKLLTP GTLTDEGMLN AKKNNFLAAV VITGENWGLA YSDISTGEFY
     TTQASDLTAL SLELSRLQPS EILFPINAPD LNRILRPGEK SDHLPPCLPD SFCYSLRPQT
     IFTLTEAKNR LLITYKMRSL EGMGCEHLPL AIRAAGGLLE YIEDTQKANQ VPLQPLKTYS
     ISEFLILDGQ TRRNLEITQT VRDGSFYGSL LWAIDRTCTA MGSRALRRWL LQPLLDSRGI
     RARQDTIQEL KDNPALRQDI RQKLREIYDI ERLSGRVGAG TANARDLLSL AASLVKLADL
     AALVASGNSP YLKALQQIPA DLEKLGQQVI AHLVESPPLH LKEGGVIREG IDAQLDALRR
     DYQEVIDWFK NLETTEKERT GISNLKVSYN KTFGYYISLP RSKADFAPKD YVRKQTLVNE
     ERYITTELKE KENIILTAVD ELNKLEYEIF SDLRRQVAEF SPEIREVATK VAALDVLAAL
     AEIAVYQGYC RPEIADGRLI DIKDGRHPVV EQSLGAGFFV PNSINLGNQE GLEYPDLIIL
     TGPNASGKSC YLRQVGLIQL LAQTGSFVPA KSAKISICDR IFTRVGAVDD LATGQSTFMV
     EMNETANILN HATDRSLVLL DEIGRGTATF DGLSIAWSVA EYLATVLQSR TIFATHYHEL
     NELASILENV ANYQVTVKEL PHEIVFLHQV RPGGADKSYG IEAGRLAGLP TSVIDRAMQV
     MGQIEKHSKI AIGLRQGIKK IKPVKSDNSP SLQQLDIFDD SK