ID   MUTS_MOOTA              Reviewed;         863 AA.
AC   Q2RJG2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Moth_1113;
OS   Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Moorella group; Moorella.
OX   NCBI_TaxID=264732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39073 / JCM 9320;
RX   PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA   Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA   Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT   "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT   thermoaceticum).";
RL   Environ. Microbiol. 10:2550-2573(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000232; ABC19427.1; -; Genomic_DNA.
DR   RefSeq; WP_011392627.1; NC_007644.1.
DR   RefSeq; YP_429970.1; NC_007644.1.
DR   AlphaFoldDB; Q2RJG2; -.
DR   SMR; Q2RJG2; -.
DR   STRING; 264732.Moth_1113; -.
DR   EnsemblBacteria; ABC19427; ABC19427; Moth_1113.
DR   KEGG; mta:Moth_1113; -.
DR   PATRIC; fig|264732.11.peg.1194; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335183"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   863 AA;  95614 MW;  B972E4EB15251F29 CRC64;
     MAREQALTPM MAQYRQIKSQ YPDCILFFRL GDFYEMFYED AEVAARELDL VLTTRGGKEA
     APMCGVPFHA ADSYLARLVG KGYKVAICEQ MEDPRQAKGL VRREVIRVVT PGTITDEKAL
     TPGGNNYLAA IVRYNGCWGL AWADASTGEF LFTTCPDQET LVDELVRLMP SEYLLPGELA
     RDTALKRLLQ IYTRGVITGW QVASNPEAAR QSLEDHFGHE ALAGVELPAA AGLAAAMILS
     FLVATQHNSL AHLEAPAAAA TTSRMFLDQA TRRNLELVTA GREQKREGSL LWVLDKTLTA
     MGARTLRRWL DQPLVDAGAI KERQEAVAEL VEGFILRQEL RERLQVVRDL ERLAGRVAYG
     TAGGRELQAL RGSLAVIPGI LELMSEVHSR LLAQVRAQLD PLDDLVDLLG RALVDDPPAS
     ITEGGIIRTG YNGEVDKLRE AATHGRDWIA SLEAEERERT GIKSLKVGYN RVFGYYIEVT
     RPNLPQVPAD YERKQTLANA ERFVTRRLQE LERQVLGAEE RLVQLEYELF QGLREEVLGV
     LPRIQATARA LGVLDALISL ATVAVDNNYT CPRVDDGTVI EIEQGRHPVV ELVGSPGTFV
     PNDTYLDQEQ YIQIITGPNM AGKSTYIRQV ALIVLLAQIG SFVPARRAHI GLVDRIFTRV
     GAADDIFAGQ STFMVEMQEV AGILKHATRR SLVILDEVGR GTSTADGLSI ARAVTEYIHN
     VIGARCLFAT HYHELVSLAE ELSGVRNYCV AVLEEGEDIT FLRTIVPGST DKSYGIHVAR
     LAGLPEQVLE RAREILEQQP RAQVRVLTKP VKKPTLTPGE VQVLEELAGY NLMAATPLEA
     MEQIFRWQKM LHKELDIVKR SRG