MUTS_MYXXD
ID MUTS_MYXXD Reviewed; 893 AA.
AC Q1D5J6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MXAN_3897;
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC Cystobacterineae; Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622;
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000113; ABF91440.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1D5J6; -.
DR SMR; Q1D5J6; -.
DR STRING; 246197.MXAN_3897; -.
DR PRIDE; Q1D5J6; -.
DR EnsemblBacteria; ABF91440; ABF91440; MXAN_3897.
DR KEGG; mxa:MXAN_3897; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_7; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..893
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335184"
FT REGION 821..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 631..638
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 893 AA; 96423 MW; 78FD95E77064091E CRC64;
MNEGAGAREI ASLTPMMRQY MEVKALHPDS LLFFRLGDFY EMFFEDAVKA SEILQITLTA
RSKGADKVPM CGVPYHAARR YIGRLVSEGL KVAICEQVEE PGNGPGIVRR EVTRVITPGM
VLDEEVLEPQ ASNFLAAVSW NDKGWGAALL EASTGEFMAL EAPGIAELAE SLSRVEPREL
LVPDGKRDAP EVAQLLARLV RTPAVAEGEA ASFEPTRAAG YLRSHFAVQS LSAFGLDDAP
LAAGAAGAAL RYLKDTQKTA AAHVDRLSRQ ERGGNLLMDE SSRANLEVLR SLRDGGRKGS
LLGVLDKTVT SLGARKLARW LASPLGSLPE IHARLDAVEE LSGRSVWREE LAGILKEVGD
LERLCGRLSL GAGNARDLRA LGLSLAQLPR VVAVLARCES PLLKSLTGPL SALPELAELL
SRAVAEEPPV TLKDGGMIRA GFHAELDKLV ALSTSGKDLL LQIEQREKER TGISSLKVRY
NKVFGYYLEV TKSNLDRVPK DYIRKQTTVN SERFVTPELK EYEEQVLTAE ERRCALEIQL
FEELRAQVVS AAPRIRSAAE AVATGDALLS FARCAAEYGY TRPEVDASVA LSITAGRHPV
VERMLGAGDS FVPNDVRLDP AEDAQLMVIT GPNMAGKSTV MRQVALTALM AQAGSFVPAK
AARIGLCDRI FTRVGAADNL ARGQSTFMVE MTETSHILHH ATNKSLIILD EIGRGTSTFD
GLSIAWAVAE HLHDTVGARA LFATHYHELV DLARERPRVK NLCVAVKEQN GKVIFLRKLV
PGGASRSYGI EVAKLAGLPP EVVGRARELL QNLESGELDD AGRPRVAVRQ PQGGRRGAST
GQLGLFGMEP AQGGTGVTPA QQKALDALKG ASIDRMTPLD ALNLLAKLQR ELE