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MUTS_MYXXD
ID   MUTS_MYXXD              Reviewed;         893 AA.
AC   Q1D5J6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=MXAN_3897;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000113; ABF91440.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1D5J6; -.
DR   SMR; Q1D5J6; -.
DR   STRING; 246197.MXAN_3897; -.
DR   PRIDE; Q1D5J6; -.
DR   EnsemblBacteria; ABF91440; ABF91440; MXAN_3897.
DR   KEGG; mxa:MXAN_3897; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..893
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335184"
FT   REGION          821..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         631..638
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   893 AA;  96423 MW;  78FD95E77064091E CRC64;
     MNEGAGAREI ASLTPMMRQY MEVKALHPDS LLFFRLGDFY EMFFEDAVKA SEILQITLTA
     RSKGADKVPM CGVPYHAARR YIGRLVSEGL KVAICEQVEE PGNGPGIVRR EVTRVITPGM
     VLDEEVLEPQ ASNFLAAVSW NDKGWGAALL EASTGEFMAL EAPGIAELAE SLSRVEPREL
     LVPDGKRDAP EVAQLLARLV RTPAVAEGEA ASFEPTRAAG YLRSHFAVQS LSAFGLDDAP
     LAAGAAGAAL RYLKDTQKTA AAHVDRLSRQ ERGGNLLMDE SSRANLEVLR SLRDGGRKGS
     LLGVLDKTVT SLGARKLARW LASPLGSLPE IHARLDAVEE LSGRSVWREE LAGILKEVGD
     LERLCGRLSL GAGNARDLRA LGLSLAQLPR VVAVLARCES PLLKSLTGPL SALPELAELL
     SRAVAEEPPV TLKDGGMIRA GFHAELDKLV ALSTSGKDLL LQIEQREKER TGISSLKVRY
     NKVFGYYLEV TKSNLDRVPK DYIRKQTTVN SERFVTPELK EYEEQVLTAE ERRCALEIQL
     FEELRAQVVS AAPRIRSAAE AVATGDALLS FARCAAEYGY TRPEVDASVA LSITAGRHPV
     VERMLGAGDS FVPNDVRLDP AEDAQLMVIT GPNMAGKSTV MRQVALTALM AQAGSFVPAK
     AARIGLCDRI FTRVGAADNL ARGQSTFMVE MTETSHILHH ATNKSLIILD EIGRGTSTFD
     GLSIAWAVAE HLHDTVGARA LFATHYHELV DLARERPRVK NLCVAVKEQN GKVIFLRKLV
     PGGASRSYGI EVAKLAGLPP EVVGRARELL QNLESGELDD AGRPRVAVRQ PQGGRRGAST
     GQLGLFGMEP AQGGTGVTPA QQKALDALKG ASIDRMTPLD ALNLLAKLQR ELE
 
 
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