ID   MUTS_NATPD              Reviewed;         856 AA.
AC   Q3IUH3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NP_0232A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR936257; CAI48207.1; -; Genomic_DNA.
DR   RefSeq; WP_011321846.1; NC_007426.1.
DR   AlphaFoldDB; Q3IUH3; -.
DR   SMR; Q3IUH3; -.
DR   STRING; 348780.NP_0232A; -.
DR   EnsemblBacteria; CAI48207; CAI48207; NP_0232A.
DR   GeneID; 3702952; -.
DR   KEGG; nph:NP_0232A; -.
DR   eggNOG; arCOG02897; Archaea.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 1024at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224425"
FT   BINDING         623..630
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  93618 MW;  137382EE53FF635E CRC64;
     MDEALGPPPA MAEKADELTP MLSQYLELCE RYDDALVLFQ VGDFYETFCE AAETTARLLE
     ITLTQREDST GTYPMAGIPI DNAESYIETL LDAGYRVAVA DQVEAAEAAS GLVDRAVTRV
     VTPGTLTETE LLAEADNNFV ACLTDGYGLA LLDVSTGDCY ATRLDRTAGV ADELERFDPA
     EAVVGPDAPT DCFGEDCMVT PYERSAFELD AARERVEAYF GSTALASDAE IRACGALLAY
     AEYARGTTTD GETEPLDYIN QLTRYDPREY MLLDAVAVRS LEIFEPRHVH GLEGAALVET
     LDETASALGG RELRDWLRRP LLDADRIERR LDAVEALVER VSDRERASER LADVYDLERL
     VAAVSRGRAD ARDLRALEST LSVVPELRAC LDDAAGESEK LASVRERLDD CTAVRELIDR
     AIVDSPPVEI TEGGVIRDGY DERLDELRAT ERDGKAWIDD LEAKERERTG IDSLKVGHNS
     VHGYYIEVTN PNLDAVPDDY QRRQTLKNSE RFYTPELKER EDEIIRAEDR ADELEYERFR
     SVREEVAAAT ERIQETARAV AELDVLCALA TVAAQYDYCR PTVDADGIYI EGGRHPVVER
     TESSFVPNPT DLPATEPLAV ITGPNMSGKS TYMRQVALTS VLTQLGSFVP AERAAVPIFD
     RVFTRVGASD DIAGGRSTFM VEMTELSTIL DAADGRSLVV LDEVGRGTST RDGYAIAQAT
     TEYLHDEAGA FTLFATHHHE LTDVAAELPQ ARNYHFAAAR TADGVEFDHD LRPGAAEASY
     GVEVAEMAGV PEAVVDRADE LLGGMRSNDT PPAAAASTDG GRVPEALLAE LEAVDLAETT
     PLEALNLLSR LKSQLD