MUTS_NEIG1
ID MUTS_NEIG1 Reviewed; 864 AA.
AC Q5F5J4;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NGO1930;
OS Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=242231;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700825 / FA 1090;
RA Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT "The complete genome sequence of Neisseria gonorrhoeae.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE004969; AAW90543.1; -; Genomic_DNA.
DR RefSeq; WP_003688085.1; NC_002946.2.
DR RefSeq; YP_208955.1; NC_002946.2.
DR PDB; 5X9W; X-ray; 3.30 A; A/B=1-814.
DR PDB; 5YK4; X-ray; 2.97 A; A/B=1-814.
DR PDBsum; 5X9W; -.
DR PDBsum; 5YK4; -.
DR AlphaFoldDB; Q5F5J4; -.
DR SMR; Q5F5J4; -.
DR STRING; 242231.NGO_1930; -.
DR PRIDE; Q5F5J4; -.
DR EnsemblBacteria; AAW90543; AAW90543; NGO_1930.
DR GeneID; 66754187; -.
DR KEGG; ngo:NGO_1930; -.
DR PATRIC; fig|242231.10.peg.2326; -.
DR HOGENOM; CLU_002472_4_0_4; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000000535; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; DNA damage; DNA repair; DNA-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..864
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224384"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
FT STRAND 3..6
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 8..17
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 21..29
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 32..36
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 38..47
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 52..57
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 60..68
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 69..71
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 72..81
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 86..93
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 95..98
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 102..105
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 129..134
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 136..145
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 146..149
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 150..156
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 161..168
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 171..176
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 188..193
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 195..198
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 200..211
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 217..220
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 223..225
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 227..243
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 244..246
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 255..257
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 267..273
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 275..277
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 281..285
FT /evidence="ECO:0007829|PDB:5X9W"
FT HELIX 287..291
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 297..308
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 314..327
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 328..330
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 331..338
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 344..352
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 358..372
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 373..375
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 384..390
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 391..394
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 395..404
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 413..415
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 425..432
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 435..452
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 459..462
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 463..465
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 466..472
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 473..476
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 490..495
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 498..531
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 533..559
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 568..570
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 572..577
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 582..585
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 586..588
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 592..596
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 602..606
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 609..612
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 613..627
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 628..630
FT /evidence="ECO:0007829|PDB:5X9W"
FT STRAND 633..640
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 645..649
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 664..673
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 674..676
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 682..687
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 696..708
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 709..712
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 715..719
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 723..726
FT /evidence="ECO:0007829|PDB:5YK4"
FT TURN 729..731
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 733..740
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 743..750
FT /evidence="ECO:0007829|PDB:5YK4"
FT STRAND 755..758
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 765..770
FT /evidence="ECO:0007829|PDB:5YK4"
FT HELIX 776..779
FT /evidence="ECO:0007829|PDB:5YK4"
SQ SEQUENCE 864 AA; 95149 MW; 612F7F3FDD52CD35 CRC64;
MSKSAVSPMM QQYLGIKAQH TDKLVFYRMG DFYELFLDDA VEAAKLLDIT LTTRGQMDGV
PIKMAGVPFH AAEQYLARLV KLGKSVAICE QVGEVGAGKG PVERKVVRIV TPGTLTDSAL
LEDKETNRIV AVSPDKKYIG LAWASLQSGE FKTKLTTADK LNDELARLQA AEILLPDSKN
APQLQTASGV TRLNAWQFAA DAGEKLLTEY FGCQDLRGFG LDSKEHAVSI GAAGALLNYI
RLTQNLMPQH LDGLSLETDS QYIGMDAATR RNLEITQTLS GKKTPTLFSI LDGCATHMGS
RLLALWLHHP LRNRAHIRAR QEAVTALESQ YEPLQCHLKS IADIERIAAR IAVGNARPRD
LASLRDSLFE LAQIDLSATG SSLLETLKAV FPETLPVAET LKAAVMPEPS VWLKDGNVIN
HGFHPELDEL RRIQNHGDEF LLDLEAKERE RTGLSTLKVE FNRVHGFYIE LSKTQAEQAP
ADYQRRQTLK NAERFITPEL KAFEDKVLTA QDQALALEKQ LFDGVLKNLR TALPQLQKAA
KAAAALDVLS TFSALAKERN FVRPEFADYP VVHIENGRHP VVEQQVRHFT ANHTDLDHKH
RLMLLTGPNM GGKSTYMRQV ALIVLLAHTG CFVPADAATI GPVDQIFTRI GASDDLASNR
STFMVEMSET AYILHHATEQ SIVLMDEVGR GTSTFDGLAL AHAIAEHLLQ KNKSFSLFAT
HYFELTYLPE AHAAAVNMHL SALEQGRDIV FLHQIQPGPA GKSYGIAVAK LAGLPVRALK
AAQKHLNGLE NQAAANRPQL DIFSTMPSEK GDEPNVDCFV DKAEEKHFEG ILAAALENLD
PDSLTPREAL SELYRLKDLC KSVS
