ID   MUTS_NEIG2              Reviewed;         864 AA.
AC   B4RPP9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NGK_2322;
OS   Neisseria gonorrhoeae (strain NCCP11945).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=521006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCCP11945;
RX   PubMed=18586945; DOI=10.1128/jb.00566-08;
RA   Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT   "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL   J. Bacteriol. 190:6035-6036(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001050; ACF30926.1; -; Genomic_DNA.
DR   RefSeq; WP_012504019.1; NC_011035.1.
DR   AlphaFoldDB; B4RPP9; -.
DR   SMR; B4RPP9; -.
DR   EnsemblBacteria; ACF30926; ACF30926; NGK_2322.
DR   KEGG; ngk:NGK_2322; -.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002564; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093635"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95175 MW;  CB208AD02752D73E CRC64;
     MSKSAVSPMM QQYLGIKAQH TDKLVFYRMG DFYELFLDDA VEAAKLLDIT LTTRGQMDGV
     PIKMAGVPFH AAEQYLARLV KLGKSVAICE QVGEVGAGKG PVERKVVRIV TPGTLTDSAL
     LEDKETNRIV AVSPDKKYIG LAWASLQSGE FKTKLTTADK LNDELARLQA AEILLPDSKN
     APQLQTASGV TRLNAWQFAA DAGEKLLTEY FGCQDLRGFG LDSKEHAVSI GAAGALLNYI
     RLTQNLMPQH LDGLSLETDS QYIGMDAATR RNLEITQTLS GKKTPTLFSI LDGCATHMGS
     RLLALWLHHP LRNRAHIRAR QEAVTALESQ YEPLQCHLKS IADIERIAAR IAVGNARPRD
     LASLRDSLFE LAQIDLSATG SSLLETLKAV FPETLPVAET LKAAVMPEPS VWLKDGNVIN
     HGFHPELDEL RRIQNHGDEF LLDLEAKERE RTGLSTLKVE FNRVHGFYIE LSKTQAEQAP
     ADYQRRQTLK NAERFITPEL KAFEDKVLTA QDQALALEKQ LFDGVLKNLR TALPQLQKAA
     KAAAALDVLS TFSALAKERN FVRPEFADYP VVHIENGRHP VVEQQVRHFT ANHTDLDHKH
     RLMLLTGPNM GGKSTYMRQV ALIVLLAHTG CFVPADAATI GPVDQIFTRI GASDDLASNR
     STFMVEMSET AYILHHATEQ IIVLMDEVGR GTSTFDGLAL AHAIAEHLLQ KNKSFSLFAT
     HYFELTYLPE AHAAAVNMHL SALEQGRDIV FLHQIQPGPA GKSYGIAVAK LAGLPVRALK
     AAQKHLNGLE NQAAANRPQL DIFSTMPSEK GDEPNVDCFV DKAEEKHFEG ILAAALENLD
     PDSLTPREAL SELYRLKDLC KSVS