ID   MUTS_NEIM0              Reviewed;         864 AA.
AC   A9M4L8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NMCC_2120;
OS   Neisseria meningitidis serogroup C (strain 053442).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=374833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=053442;
RX   PubMed=18031983; DOI=10.1016/j.ygeno.2007.10.004;
RA   Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z.,
RA   Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z.,
RA   Liang X., Xu J., Jin Q.;
RT   "Characterization of ST-4821 complex, a unique Neisseria meningitidis
RT   clone.";
RL   Genomics 91:78-87(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000381; ABX74237.1; -; Genomic_DNA.
DR   RefSeq; WP_012222182.1; NC_010120.1.
DR   AlphaFoldDB; A9M4L8; -.
DR   SMR; A9M4L8; -.
DR   EnsemblBacteria; ABX74237; ABX74237; NMCC_2120.
DR   KEGG; nmn:NMCC_2120; -.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001177; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075557"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95294 MW;  59DEB161A72D86A6 CRC64;
     MSKSAVSPMM QQYLGIKAQH TDKLVFYRMG DFYEMFFDDA VEAAKLLDIT LTTRGQMDGV
     PIKMAGVPFH AAEQYLARLV KLGKSVAICE QVGEVGAGKG PVERKVVRIV TPGTLTDSAL
     LEDKETNRIV AVSPDKKYIG LAWASLQSGE FKTKLTTVDK LDDELARLQA AEILLPDSKN
     TPQLQTASGV TRLNAWQFAA DAGEKLLTEY FGCQDLRGFG LDGKEHAVAI GAAGALLNYI
     RLTQNLMPQH LDGLSLETDS QYIGMDAATR RNLEITQTLS GKKSPTLMST LDLCATHMGS
     RLLALWLHHP LRNRAHIRAR QEAVAALESQ YKPLQCRLKN IADIERIAAR IAVGNARPRD
     LAALRDSLFA LSEIDLSANG SSLLETLKAV FPETLPVAET LKAAVMPEPA VWLKDGNVIN
     HGFHPELDEL RRIQNHGDEF LLDLEAKERE RTGLSTLKVE FNRVHGFYIE LSKTQAEQAP
     ADYQRRQTLK NAERFITPEL KAFEDKVMTA QEQALALEKQ LFDGVLKNLQ TALPQLQKAA
     KAAAALDVLS TFSALAKERN FVRPEFADYP VIHIENGRHP VVEQQVRHFT ANHTNLDHKH
     RLMLLTGPNM GGKSTYMRQV ALIVLLAHTG CFVPADAATI GPIDQIFTRI GASDDLASNR
     STFMVEMSET AYILHHATEQ SLVLMDEVGR GTSTFDGLAL AHAVAEHLLQ KNKSFSLFAT
     HYFELTKLPE AHATAVNMHL SALEQGQDIV FLHHIEPGPA SKSYGIAVAK LAGLPVRALK
     SAQKHLNELE DQAAANRPQL DIFSTMPSEK GDEPNVDSFV DKAEEKHFEG ILAAALEKLD
     PDSLTPREAL SELYRLKDLC KSVS