ID   MUTS_NEIMA              Reviewed;         864 AA.
AC   Q9JWT7; A1IP93;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NMA0247;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL157959; CAM07553.1; -; Genomic_DNA.
DR   PIR; C82019; C82019.
DR   RefSeq; WP_002246565.1; NC_003116.1.
DR   AlphaFoldDB; Q9JWT7; -.
DR   SMR; Q9JWT7; -.
DR   EnsemblBacteria; CAM07553; CAM07553; NMA0247.
DR   KEGG; nma:NMA0247; -.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; NMEN122587:NMA_RS01280-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115111"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95249 MW;  8C212FFF80C16540 CRC64;
     MSKSAVSPMM QQYLGIKAQH TDKLVFYRMG DFYEMFFDDA VEAAKLLDIT LTTRGQVDGE
     PVKMAGVPFH AAEQYLARLV KLGKSVAICE QVGEVGAGKG PVERKVVRIV TPGTLTDSAL
     LEDKETNRIV AVSPDKKYIG LAWASLQSGE FKTKLTTVDK LDDELARLQA AEILLPDSKN
     APQLQTASGV TRLNAWQFAA DAGEKLLTEY FGCQDLRGFG LDGKEHAVAI GAAGALLNYI
     RLTQNLMPQH LDGLSLETDS QYIGMDAATR RNLEITQTLS GKKSPTLMST LDLCATHMGS
     RLLALWLHHP LRNRAHIRAR QEAVAALESQ YKPLQCRLKN IADIERIAAR IAVGNARPRD
     LASLRDSLFE LAQIDLSANG SSLLETLKAV FPENLSTAEQ LRQAILPEPS VWLKDGNVIN
     HGFHPELDEL RRIQNHGDEF LLDLEAKERE RTGLSTLKVE FNRVHGFYIE LSKTQAEQAP
     ADYQRRQTLK NAERFITPEL KAFEDKVLTA QEQALALEKQ LFDGVLKNLQ TALPQLQKAA
     KAAAALDVLS TFSALAKERN FVRPEFADYP AIHIENGRHP VVEQQVRHFT ANHTNLDHKH
     RLMLLTGPNM GGKSTYMRQV ALIVLLAHTG CFVPADAATI GPIDQIFTRI GASDDLASNR
     STFMVEMSET AYILHHATEQ SLVLMDEVGR GTSTFDGLAL AHAVAEHLLQ KNKSFSLFAT
     HYFELTYLPE AHAAAVNMHL SALEQGQDIV FLHQIQPGPA GKSYGIAVAK LAGLPVRALK
     SAQKHLNGLE NQAAANRPQL DIFSTMPSEK GDEPNVGNFV DKAEEKHFEG ILAAALEKLD
     PDSLTPREAL SELYRLKDLC KSVS