ID   MUTS_NITEC              Reviewed;         880 AA.
AC   Q0AEI7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Neut_2022;
OS   Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Nitrosomonadaceae; Nitrosomonas.
OX   NCBI_TaxID=335283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 101675 / C91 / Nm57;
RX   PubMed=17991028; DOI=10.1111/j.1462-2920.2007.01409.x;
RA   Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S.,
RA   Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.;
RT   "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas
RT   eutropha C91: implications for niche adaptation.";
RL   Environ. Microbiol. 9:2993-3007(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000450; ABI60245.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0AEI7; -.
DR   SMR; Q0AEI7; -.
DR   STRING; 335283.Neut_2022; -.
DR   EnsemblBacteria; ABI60245; ABI60245; Neut_2022.
DR   KEGG; net:Neut_2022; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001966; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335186"
FT   BINDING         635..642
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  97972 MW;  AA73D1676E856D01 CRC64;
     MTTSGNSINK PDHSAHTPMM QQYLRIKTQH TDKLLFYRMG DFYELFYEDA EKAARLLDIT
     LTHRGSSAGE PIKMAGVPFH AADQYLAKLV KLGESIAICE QIGDPATSKG PVERQVVRII
     TPGTLTDAGL LEERGNSIVL TLALHHGVIG LAWLNLAAGD MRVLETSPDN LASELERLHP
     SEILLPESLA LPVILNSFTA PKRLPDWQFD YEHAMQQLTR QFGTRDLNAF GCEELRAAIM
     AAGALFEYVR LTQHTATDES ATQVLGHLQT LRVERPETYL RMDAATRRNL EITLTLRGEE
     APTLSSLLDI CATSMGSRLL RHWLHHPLRN RITLQQRLDA VSDLIGAKPG ILYAGIRERL
     KHIADIERIT SRIALRTARP RDLSGLRDSL TALPEIIKLI TTSTAIAIHR FVPAMEPDTT
     LTQLLVHALQ PVPGAVIREG GVIADGYDAE LDELRALQKN CGEFLLQLEA RERERTGIPT
     LKVEYNRVHG FYIEVTRIHG EKIPADYRRR QTLKNAERYS IPELQVFENK TLTAREQALA
     QEKKLYEQLL EQLADFIIPL QEIARSVAEL DVLCAFAERA DLFGYTKPVF TDDPALDIEA
     GRHPVVENQI EQYIANDIQL GAVTREGRQM LIITGPNMGG KSTYMRQTAL IILLAHCGSF
     VPAGSARIGP IDQIFTRIGA ADDLAGGRST FMVEMTEAAS ILRNATAQSL VLVDEIGRGT
     STFDGLALAF AIARHLLTQN QSYTLFATHY FELTRLAEEF PQAINVHVTA VEHKRRIVFL
     HRIEEGSASR SYGLHVAALA GVPDKVIRNA GKILAQLEQE ALSKSPQQTL FETIEENAEA
     APASAHPVLD YLEQLHPDEL TPREALEQLY LIKSMANRIK