ID   MUTS_NITEU              Reviewed;         873 AA.
AC   Q82U08;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NE1705;
OS   Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC
OS   14298).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Nitrosomonadaceae; Nitrosomonas.
OX   NCBI_TaxID=228410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298;
RX   PubMed=12700255; DOI=10.1128/jb.185.9.2759-2773.2003;
RA   Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L.,
RA   Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A.,
RA   Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.;
RT   "Complete genome sequence of the ammonia-oxidizing bacterium and obligate
RT   chemolithoautotroph Nitrosomonas europaea.";
RL   J. Bacteriol. 185:2759-2773(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL954747; CAD85616.1; -; Genomic_DNA.
DR   RefSeq; WP_011112259.1; NC_004757.1.
DR   AlphaFoldDB; Q82U08; -.
DR   SMR; Q82U08; -.
DR   STRING; 228410.NE1705; -.
DR   EnsemblBacteria; CAD85616; CAD85616; NE1705.
DR   KEGG; neu:NE1705; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q82U08; -.
DR   Proteomes; UP000001416; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115113"
FT   BINDING         628..635
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  97304 MW;  DC80358D0E1776AF CRC64;
     MNKAEQSSHT PMMQQYLRIK AQHTDKLLFY RMGDFYELFY EDAEKAAKLL DITLTQRGSS
     AGEPIKMAGV PFHAADQYLA RLVRLGESIA ICEQTGDPAT SKGPVERQVI RILTPGTLTD
     AGLLEERSNS IVLALALHRG SIGLAWLNLA AGDMRVLETS SDNLTSELER LHPAEILLPE
     SLDLPATLNN FAGPKRLPDW QFDYEHAMQQ LTRQFGTRDL NAFGCEDLHA AIMAAGALFE
     YVRLTQQTAT DGSSGQLPGH LHTLQVERQD AYLRMDAATR RNLEITLTLR GEDAPTLSSL
     LDTCSTGMGS RLLRHWLHHP LRNRITLQQR LDTVSDLIGA QPETLYAGIR QQFKHIADIE
     RITSRIALRT ARPRDLSGLR DSLMRLPGII ELIATSAAAA VHRFIPPMQP DPLLTQLLVR
     ALQPVPGAVI REGGVIADGF DAELDELRGL QGNCDEFLLQ LEARERERTG IPNLKVEYNR
     VHGFYIEVTR AQGEKIPPDY RRRQTLKNAE RYIIPELQAF EHKTLSAREQ ALAREKMLYE
     RLLEQLADFI IPLQEIARSV AELDVLCAFA ERAALSGYTK PVFTDDPVLI IEAGRHPVVE
     NQVEHYIAND VQLGAITREN RQMLVITGPN MGGKSTYMRQ TALTVLLAHC GSFVPAQIAR
     IGPIDQIFTR IGAADDLAGG RSTFMVEMTE AAGILRNATA QSLVLVDEIG RGTSTFDGLA
     LAFAIARHLL TQNQSYTLFA THYFELTRLA EEFPQAVNIH VTAVEHKRRI VFLHRIEEGP
     ASRSYGLHVA ALAGVPDRVI RNAAKILARL EQETLSRSPQ QTLFETVEEN AKAVPASVHP
     VLDYLERIHP DELTPRGALE QLYLIKSMLN QTD