ID   MUTS_NITHX              Reviewed;         907 AA.
AC   Q1QQJ4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Nham_0614;
OS   Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10229 / NCIMB 13809 / X14;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L.,
RA   O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T.,
RA   Gentry M.E., Bruce D., Richardson P.;
RT   "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000319; ABE61503.1; -; Genomic_DNA.
DR   RefSeq; WP_011509207.1; NC_007964.1.
DR   AlphaFoldDB; Q1QQJ4; -.
DR   SMR; Q1QQJ4; -.
DR   STRING; 323097.Nham_0614; -.
DR   EnsemblBacteria; ABE61503; ABE61503; Nham_0614.
DR   KEGG; nha:Nham_0614; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001953; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..907
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335185"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   907 AA;  97501 MW;  55299C6EBA57E416 CRC64;
     MTIQPAVPTS PTNAAPEAAR VTPMMEQYLE IKAANPGLLL FYRMGDFYEL FFEDAEIASC
     TLGITLTKRG KHQGADIPMC GVPVERSDDY LHRLIAAGHR VAVCEQMEDP AAARRRGNKS
     VVRRDVVRLI TPGTLTEDTL LDARANNYLL ALARARASSG GNRIALAWID ISTAEFIVTE
     CSTGELAATL ARINPNEVIV SDALYGDPDM AALLRELPSV TPLTRDVFDG ATAERRLCDY
     FAVATMDGLS AMSWLEATAA AAAVTYVDRT QIGKRPPLSP PSREAAGSTM AIDPATRANL
     ELTRTLAGER RGSLLDAIDR TMTAAGSRLL AQRLAAPLTD IAAIARRLDA VAAFTSDSAA
     RDDIRTILRT APDMSRALAR LSVGRGGPRD LAGLRDGIMA ADRTLARLSA LPDPPQDIVA
     AMQALRRPSR ELARELGEAL AENLPLMKRD GGFAREGYEP TLDEARKLRD DSRLVVAAMQ
     ARYTEETGVK TLKIRHNNVL GYFVEVTAQH GDKLTSAPLN ATFIHRQTLA GQVRFTTSEL
     GEIEARIANA GDRALGLELE IFDRLAAVVV EAGDDLRAAA HAFAQLDVAA SLAKLATDEN
     FTRPEVDASL GFAIEGGRHP VVEQALKRAG QPFIANACDL SPGPGQTSGQ IWLLTGPNMA
     GKSTFLRQNA LIALMAQIGS FVPATRARIG MIDRLFSRVG AADDLARGRS TFMVEMVETA
     VILNQASERA LVILDEIGRG TATFDGLSIA WAAIEHLHEA NKCRALFATH YHELTALSAK
     LPRLFNATVR VKEWHGEVVF LHEVLPGAAD RSYGIQVAKL AGLPPSVVAR AKSVLAKLEA
     QDRGSTVRAL VDDLPLFAVP SRAADESAPP GEAAPLIEAL KALHPDEMSP REALEALYAL
     KAKLPKP