ID   MUTS_NITMU              Reviewed;         902 AA.
AC   Q2YB94;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Nmul_A0670;
OS   Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Nitrosomonadaceae; Nitrosospira.
OX   NCBI_TaxID=323848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25196 / NCIMB 11849 / C 71;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC
RT   25196.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000103; ABB73977.1; -; Genomic_DNA.
DR   RefSeq; WP_011380027.1; NZ_FNVK01000003.1.
DR   AlphaFoldDB; Q2YB94; -.
DR   SMR; Q2YB94; -.
DR   STRING; 323848.Nmul_A0670; -.
DR   EnsemblBacteria; ABB73977; ABB73977; Nmul_A0670.
DR   KEGG; nmu:Nmul_A0670; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002718; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..902
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335187"
FT   BINDING         647..654
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   902 AA;  99553 MW;  A31E504FAE037AE8 CRC64;
     MSQSSKARLS TDPTVFEAVL NNHTPMMQQY LRIKAQHPDM LMFYRMGDFY ELFFDDAEKA
     AKLLDITLTR RGTSAGEPIK MAGVPYHAAE QYLAKLVKLG ESVVICEQVG DPATSKGPVE
     RQVTRIITPG TLTDAALLED KRDSALLALL VHESTLGLAW LNLAAGQFSV METSVNNLTA
     ELERLKPAEI LLPESLNLAG INDRVIQEKL CVKHLPAWQF DTAAAVRNLS RQFGTHDLSG
     FGCEDLDVSL GAASALLDYT RLTQGASIGH IKGLRVERED TYLRMDATTR RNLEISETIR
     GDAAPTLLSL LDTCSTNMGS RLLCHWLHHP LRDRGLIQNR LNGVSFLMGE AGSGPCLSVR
     DCLKRVTDIE RITARIALKS ARPRDLSGLR DSLKRLPAVN NAVAGTATTS SGGSDVSAHV
     AALIHSMAPD NALVALLEKS LKEEPEVMLR TGGVIADGYD AELDELRAIH NNCDEFLLQL
     ETREKARTGI ANLKVEYNRL HGFYIEVTHA HTEKIPDDYR RRQTLKNAER YITPELKAFE
     EKALSAQSRA LEREKLLYGE LLDMLSQYID HLQQVARSVA ELDVLATFAE RALALDYSLP
     LFTSDSVIEI QAGRHPVVEK QVDSFIANDV QLGARTGGRR QMLVITGPNM GGKSTYMRQV
     ALIALLAHCG SFVPARSALI GPLDQLFTRI GASDDLAGGR STFMMEMTEA ANILHNATAQ
     SLVLMDEVGR GTSTFDGLAL AFAIARYLLE KNRSYTLFAT HYFELTRLAE EFAQVANVHL
     RAVEHKHHIV FLHAVNEGPA SQSYGLQVAA LAGVPDPVIR TARRYLLKLE QEALSNQPQG
     DLFSRDDLFW KQDRMPEGSV DKNDSAPEHP VLALLRTIVP DDLSPKQALE QLYGLKKAAE
     KE