ID   MUTS_NITOC              Reviewed;         863 AA.
AC   Q3JCL5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Noc_0919;
OS   Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB
OS   11848 / C-107).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC   Nitrosococcus.
OX   NCBI_TaxID=323261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107;
RX   PubMed=16957257; DOI=10.1128/aem.00463-06;
RA   Klotz M.G., Arp D.J., Chain P.S.G., El-Sheikh A.F., Hauser L.J.,
RA   Hommes N.G., Larimer F.W., Malfatti S.A., Norton J.M., Poret-Peterson A.T.,
RA   Vergez L.M., Ward B.B.;
RT   "Complete genome sequence of the marine, chemolithoautotrophic, ammonia-
RT   oxidizing bacterium Nitrosococcus oceani ATCC 19707.";
RL   Appl. Environ. Microbiol. 72:6299-6315(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000127; ABA57431.1; -; Genomic_DNA.
DR   RefSeq; WP_011330516.1; NC_007484.1.
DR   AlphaFoldDB; Q3JCL5; -.
DR   SMR; Q3JCL5; -.
DR   STRING; 323261.Noc_0919; -.
DR   PRIDE; Q3JCL5; -.
DR   EnsemblBacteria; ABA57431; ABA57431; Noc_0919.
DR   KEGG; noc:Noc_0919; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006838; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224386"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   863 AA;  96081 MW;  CB15A68207E42488 CRC64;
     MPANDPQKPH TPMMQQYLRI KAEYPNTLLL YRMGDFYELF YDDAQRASEL LDIALTSRGR
     SAGEPIPMAG IPYHALDSYL ARLVRQGESV AICEQIGNPA ASKGPVERQV VRIITPGTVT
     EEALLEARRD NLLAALQKEG DVFGFAVLDL CSGRFNILEV ASESAATSEL ARIRPAELLV
     SEDLALILVD SKTEAVVRPL PPWYFDRESA QRQLCRQFGT QDLAGFGCEE MKTAIAAAGC
     LLHYVQDTQR TQFPHIHALQ VERQETSIIL DPSTRRNLEL EESLSGDSGR NTLIAVLDHT
     ATAMGSRLLR RYLHRPLRDQ TLLKQRQQAL ATLLEGGLSD VLQTLLRGIG DIERILSRVA
     LRSARPRDLV QFRQALGLLP KIQESLLQLN RDSLLLQSLQ EDLGPFPNLH ELLQRAICEN
     PPVLIRDGGV IALGFDSELD ELRHLSGNAG QFLVKLEQRE RERTKIPTLK VGYNKVHGYY
     LEITRAQAHQ APPDYIRRQT LKGAERYITP ELKGFEDQVL SARERALARE KALYEELLEQ
     FMEPLPALRA CANALAELDV LHNLAERAKT LEYVAPLLSD QPGIFIERGR HPVVEQTLED
     PFVPNDLTLH EARRMLIITG PNMGGKSTYM RQTALIVLLA HIGSFVPARR AVIGPIDRIF
     TRIGAADDLA GGRSTFMVEM TETANILHNA TEHSLVLLDE VGRGTSTFDG LSLAWAVVSH
     LANKVRSLTL FATHYFELTT LPECLPGVVN LHLTATEHKE HIVFLHAVKE GPASQSYGLQ
     VAALAGVPQE IIAQARQQLM ELENNTWQKS INGGGPQLDL LAPPADHPAV QILQDLDPDE
     LTPRQALEKL YELKQLLDLA VTH