ID   MUTS_NITWN              Reviewed;         888 AA.
AC   Q3SVD4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Nwi_0490;
OS   Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 /
OS   NCIMB 11846 / Nb-255).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255;
RX   PubMed=16517654; DOI=10.1128/aem.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L.,
RA   Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J.,
RA   Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium
RT   Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000115; ABA03757.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3SVD4; -.
DR   SMR; Q3SVD4; -.
DR   STRING; 323098.Nwi_0490; -.
DR   EnsemblBacteria; ABA03757; ABA03757; Nwi_0490.
DR   KEGG; nwi:Nwi_0490; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002531; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..888
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224385"
FT   REGION          249..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   888 AA;  95772 MW;  3824B5221D177F8C CRC64;
     MMEQYLEIKA ANPGLLLFYR MGDFYELFFE DAEIASRALG ITLTKRGKHQ GADIPMCGVP
     VERSDDYLHR LIAAGHRVAV CEQTEDPSAA RKRGNKSVVR RDVVRLVTPG TLTEDTLLDA
     RANNYLLALA RARASSGVDR FALAWIDIST AEFMVTECGA NELAATLARI NPNEVIVSDT
     LHGDPDLGAL LRELPSVTPL PRDTFDGATA ERRLCDYFAV ATMDGLSAMS RLEATAAAAA
     VTYIDRTQIG QRPPLSPPSR EASGSTMAID PATRANLELT RTLAGERRGS LLDAIDRTMT
     AAGSRLLAQR LAAPLTDTAA ITRRLDAVAA LTADGAARDD IRAILRTAPD MSRALARLSL
     GRGGPRDLAG LRDGVMAADQ TLARLAGLSD PPEGIAAAMQ ALRGPSRELA RELGNALSEN
     LPLMKRDGGF VREGYDTALD EARKLRDDSR LVVAAMQARY AEETGVKTLK IRHNNVLGYF
     VEVTAQHANR LMSAPLNATF IHRQTLAGQV RFTTSELGEI EARIANAGER ALGLELDIFD
     RLAAMAIRNG DEIRNAAHAF AQLDVAASFA KLAIDENYTR PDIDASLSFA IEGGRHPVVE
     QALKRTGQPF IANACDLSPP PPPVEGSGES GQIWLLTGPN MAGKSTFLRQ NALIALMAQV
     GSFVPASRAR IGIIDRLFSR VGAADDLARG RSTFMVEMVE TAVILNQASE RALVILDEIG
     RGTATFDGLS IAWATIEHLH ESNRCRALFA THYHELTALS AKLPRLFNAT VRVKEWHGEV
     VFLHEVLPGA ADRSYGIQVA RLAGLPPSVI ARAKSVLAKL EAQDRGSTVR VLVDDLPLFA
     VTSRTGESAP TGETSPLIEA LKSLHPDEMS PREALDALYA LKAKLPKQ