ID   MUTS_NOSP7              Reviewed;         892 AA.
AC   B2J434;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Npun_R3761;
OS   Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=63737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29133 / PCC 73102;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA   Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT   "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001037; ACC82146.1; -; Genomic_DNA.
DR   RefSeq; WP_012410117.1; NC_010628.1.
DR   AlphaFoldDB; B2J434; -.
DR   SMR; B2J434; -.
DR   STRING; 63737.Npun_R3761; -.
DR   EnsemblBacteria; ACC82146; ACC82146; Npun_R3761.
DR   KEGG; npu:Npun_R3761; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; B2J434; -.
DR   Proteomes; UP000001191; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..892
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118688"
FT   REGION          663..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         696..703
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   892 AA;  98858 MW;  F259F9BE59E7EE34 CRC64;
     MTASHSETPS TKPDASTFIS DHLQVDRSKL SQMYLHYVET KDKYPHAVLL YRVGDFFECY
     FQDAVKLAQE LELVLTSKQA GEQGRVAMSG VPHHAWERYA TLLVEKGYAV VICDQVEDAS
     EAAGRLVRRE VTRILTPGTL LEEGMLKSSR NNYLAAVVIA ANHWGLAYAD ISTGEFLTTQ
     GSDLEHLTQE LMRLQPSEVL VPTNAPDLGS LLRPGETSPH LPECLPPSFC YSLRSQVPFS
     QGEARPRLLQ KFKVRSLEGL GCDRFPLAVR AAGGLLEYLE DTQKENPVPL QRLRTYTVTD
     YLIVDSQTRR NLEITQTVRD GTFHGSLLWS LDRTSTAMGG RALRRWLLQP LLDIKGIRAR
     QDTIQELMEN TPLRQDLRQL LRQIYDLERL TGRAGSGTAN ARDLVALADS LSRLPELSHL
     VTESHSPFLK ALQKVPSVLE ELAQKLHAHL VESPPILIKE GGLIRPSVNP LLDERKATVE
     ADQQWIANLE VDERAKTGIS TLKVGFNKTF GYYISISRTK ADQVPANYIR KQTLTNEERY
     ITPDLKEREA RILSARDDLN QLEYEIFTAL REEVAQEAEV IRNLSRAVAA ADVLCGLAEL
     AVHQGYCRPE MLSGREINIV DGRHPVVEQS LPAGFFVPNS TQLGQESLVS SHLSLADNQE
     QITNTSLREA APTTTLSTSD QGQMTNDNPD LIILTGPNAS GKSCYLRQVG LIQLMAQIGS
     FVPARLAKLG ICDRIFTRVG AVDDLATGQS TFMVEMNETA NILNHATSRS LVLLDEIGRG
     TATFDGLSIA WAVAEYIAVD IRARTIFATH YHELNELASI VPNVANYQVT VKELPDQIIF
     LHQVQPGGAD KSYGIEAGRL AGLPAVVIQR AKQVMGQIEK HSKIAMGLQN LD