ID   MUTS_OCEIH              Reviewed;         867 AA.
AC   Q8CXG6;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=OB1631;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000028; BAC13587.1; -; Genomic_DNA.
DR   RefSeq; WP_011066031.1; NC_004193.1.
DR   AlphaFoldDB; Q8CXG6; -.
DR   SMR; Q8CXG6; -.
DR   STRING; 221109.22777314; -.
DR   EnsemblBacteria; BAC13587; BAC13587; BAC13587.
DR   KEGG; oih:OB1631; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q8CXG6; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..867
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115114"
FT   BINDING         606..613
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   867 AA;  99724 MW;  616F27D0C880C60E CRC64;
     MAKLTPMMEQ YIQIKNEYKD AFLFYRLGDF YELFYEDATR AAQELEITLT KRAGGKGDPI
     PMCGVPYHSA ENYIKTLIDR GYKVAICEQV EDPKTAKGVV KREVVQMITP GTVMESTMLT
     DGENNYIGSL SHFQDGSYVI VYNDLSTGEN RLAFINDGWD AVIHEFYNQP IKEIVISSNL
     PEELQIQLKE RLNVTLSYQD EVTFNAEFRE LSENLNDERL MKAFSRLLNY IQTTQKRSLH
     HLQKAEVIEL KKYMSLDMYS KRNLELTETI MKKSKHGSLL WVLDKTVTAM GARTLKKWLE
     RPLLSKQKIN ERLEVVQGFY DGFMERESLR DLLKSVYDLE RLSGRIAFGN VNARDLIQLK
     QSLSRIPAIQ ETLRQFDQPE ITRLAEMLIY PEQMVESLEK SIVDEPPISI KEGSLIKEGY
     HDQLDTYRDA SRNGKKWIAQ LEHQEREETG IRSLKVGYNR VFGYYIEITK PNLHLLPEGR
     YERRQTLTNA ERFVNEELKE KEKLILEAEE KSVELEYDLF IQIRDQIKEE IPLIQQLAHI
     ISQMDVLQSF ATVSESNNYV RPDFNDEQLQ VTKGRHPVVE QVMKDGTFVP NDVVFDKSQN
     MLLITGPNMS GKSTYMRQVA LTSIMGQIGC FIPAEQATLC VFDQIFTRIG AADDLVSGQS
     TFMVEMLEAR HAISNATDRS LILLDEIGRG TSTYDGMALA QAIVEYIHHN IAAKTLFSTH
     YHELTALEDS LHHLKNIHVR AEEHEGNVVF LHQIKEGAAD QSYGIHVAKL ADLPNELIER
     ASVILEELED DSNKKPTPTK DKLESGQLSF FIEESNKKKA EMPKQEKTHN NQEQSVIEDL
     KNVNVLDLTP LEAMNELYRL QKGLKQY