ID   MUTS_OLEA2              Reviewed;         904 AA.
AC   Q30ZX3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Dde_1976;
OS   Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)
OS   (Desulfovibrio alaskensis).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Oleidesulfovibrio.
OX   NCBI_TaxID=207559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1058 / DSM 17464 / G20;
RX   PubMed=21685289; DOI=10.1128/jb.05400-11;
RA   Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L.,
RA   Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R.,
RA   Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S.,
RA   Nolan M., Lapidus A.L., Palumbo A.V., Wall J.D.;
RT   "Complete genome sequence and updated annotation of Desulfovibrio
RT   alaskensis G20.";
RL   J. Bacteriol. 193:4268-4269(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000112; ABB38773.1; -; Genomic_DNA.
DR   RefSeq; WP_011367883.1; NC_007519.1.
DR   AlphaFoldDB; Q30ZX3; -.
DR   SMR; Q30ZX3; -.
DR   STRING; 207559.Dde_1976; -.
DR   EnsemblBacteria; ABB38773; ABB38773; Dde_1976.
DR   KEGG; dde:Dde_1976; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_6_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002710; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..904
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224368"
FT   REGION          825..869
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        844..866
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   904 AA;  102014 MW;  F31A910C7048B9E9 CRC64;
     MTSHSPKLTP MFEQYMNIKA EYPDALLFYR MGDFYELFFE DAEVAARELQ IALTCRNPNA
     ENKVPMCGVP HHSARSYISQ LVDKGYKVAI CEQMEDPREA KGLVKRGVIR VLTSGTALED
     ENLSPKAHTY LGALCWDKSE GAGGFAWVDF STGEWSGLQS RKEQELWQWV QKMAPRELLL
     ADTLTPPASL ELTETQFSKV PERAYFDYKR SAEKIMSAQQ VAELGALGLE NRKELVRACG
     ALLTYLSQTQ KQDLNHLCQF KPLNLNRHLL LDEITERNLE LFRRLDGRKG KGTLWHVLDH
     TVTPMGGRLL QERLKHPWRE QAPIDETQEA VSHFFAHNTL RRQLREALDT VYDIERLSTR
     IFLNRATPRD YVALRQSLKA LPAVRELLEA PQTGDGRYAT PEEQLGAALP PFLHRMLKSW
     DDLADYHDLL EKALVDNPPH VITEGGLFRQ GFHPALDELM DLSEHGASKL HDLLAEVQQT
     TGISKIKLGN NRVFGYYFEV PKSVSEELPD TFVRRQTLAN AERYTSERLK ELEEKLFSAA
     DKRKTMELKL FQQLREHVAQ ARPRVLFMAD LLATLDHWQG LAEAARHWNW VRPVLHDGQD
     IVIREGRHPV VEAVQGPAGF IPNDLRIDDQ RRLLLITGPN MAGKSTVLRQ AAIICILAQI
     GSFVPAREAR IGLCDRIFSR VGASDNLAQG QSTFMVEMME TARILRQATR RSLVILDEIG
     RGTSTFDGLA LAWAVVEELM KKQQAGIRTL FATHYHELTS LEGTIPGVHN MNIAIKEWGG
     EIVFLRRLVP GPSDRSYGVE VAKLAGVPQN VVQRARQILE LLEQKSKADG TRRPASYHEA
     QPLLPGMPEP PSTASAEPPQ TVTPPEPPVL TALRDLDTDN LTPLEALTVL TEWKTLWGAG
     KNEC