ID   MUTS_ORITB              Reviewed;         889 AA.
AC   A5CDU2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=OTBS_1034;
OS   Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=357244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boryong;
RX   PubMed=17483455; DOI=10.1073/pnas.0611553104;
RA   Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y.,
RA   Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S.,
RA   Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.;
RT   "The Orientia tsutsugamushi genome reveals massive proliferation of
RT   conjugative type IV secretion system and host-cell interaction genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM494475; CAM80100.1; -; Genomic_DNA.
DR   RefSeq; WP_011944749.1; NC_009488.1.
DR   AlphaFoldDB; A5CDU2; -.
DR   SMR; A5CDU2; -.
DR   EnsemblBacteria; CAM80100; CAM80100; OTBS_1034.
DR   KEGG; ots:OTBS_1034; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001565; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..889
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335189"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   889 AA;  100315 MW;  6E8A6DFD565B3210 CRC64;
     MLTKEDFRNK YQYHQATPML QQYLDIKFTH QCCILLFRVG DFYELFFDDA IVVSKLLGLI
     LAKKGKHAGQ DLPMCGIPYH ALESYLPRLV EQEHKVALCE QLESPEEAKK RNGYKAVVKR
     EVVRIITSGT ITEESLIKAN VPNYLAAIVI HKDIASIGYC DVSTAEFIVI DVAIHNLTSE
     LSRINPKEII LSESLQHNSG LLALFDNYKQ KIVYQVESYF SFNKAQRVIQ NYYEIITIDS
     IGSLNSTQVS AVGAILEYLS IMQKHSKSKL PFPQIVSYEN FMLIDASARK NLELTSTLSG
     NFKGSLLSII DATVTNQGGR LLHKFLSTPL AEVNLINSRL QITDFFYQNL QLVENLRQLV
     KLVPDIERAL SRILIAKALP KDLESIKISL KIALSIKKEL NKVLEEGNTP KYLEEIYNPL
     FGDNELYELL DSALLDDLSN SANDCGFIKS SYSTKLEELR NLIHNSSNFI EQLKLQYRQE
     TCIETLKICH NNVWGMFIEV SSKNAHKITD SKFVHKQTTT TAVRFTTTEL QTLEAKMLNA
     KTMAAALEQE ILAELCKAIS LKSEKLSHLA KSISLIDVFC NFAYISHEYN YCRPEITSDL
     AFNIVDGRHA VIEKLITKKH ESFISNDCNL QNDQRIWLIT GPNMAGKSTF LRQNAIIVIL
     AQIGCYVPAQ SAQIGVVDKL FSRIGAADDL ASGQSTFMVE MVETSVILAQ STFMSLVILD
     EIGRGTSTYD GISIAWSCLE YIHSNIRCRC LFATHYHELV DLASKLLSLK NFTVKIHDSN
     DKLSFLYKII EGAANKSYGI HVAELAGLPR IVLNRAKEIL LELEHNKVNI NQSNNNITKS
     IDIAVPPYPV KTIEIIKQLN PDQLTPKEAL SIIYKIKNTI LLEEDEKMI