ID   MUTS_ORITI              Reviewed;         889 AA.
AC   B3CQY2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=OTT_0431;
OS   Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=334380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ikeda;
RX   PubMed=18508905; DOI=10.1093/dnares/dsn011;
RA   Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M., Fukuhara M.,
RA   Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T., Oshima K.,
RA   Tamura A., Hattori M., Hayashi T.;
RT   "The whole-genome sequencing of the obligate intracellular bacterium
RT   Orientia tsutsugamushi revealed massive gene amplification during reductive
RT   genome evolution.";
RL   DNA Res. 15:185-199(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008981; BAG39889.1; -; Genomic_DNA.
DR   RefSeq; WP_012461104.1; NC_010793.1.
DR   AlphaFoldDB; B3CQY2; -.
DR   SMR; B3CQY2; -.
DR   PRIDE; B3CQY2; -.
DR   EnsemblBacteria; BAG39889; BAG39889; OTT_0431.
DR   GeneID; 66652602; -.
DR   KEGG; ott:OTT_0431; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001033; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..889
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093636"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   889 AA;  100414 MW;  7CB6CC2629FB87F7 CRC64;
     MLTQEDFRNK YQYHQATPML QQYLDIKFTH QCCILLFRVG DFYELFFDDA IVVSKLLGLV
     LAKKGKHAGQ DLPMCGIPYH ALESYLPRLV EQEHKVALCE QLESPEEAKK RNGYKAVVKR
     EVVRILTSGT ITEESLIKAN APNYLAAIVI YKDIASIGYC DVSTAEFIVI DVSIHNLTSE
     LSRINPKEII LSESLQHNSS LLALFDNYKQ KIVYQVESYF SFNKAQRTIQ NYYEIITIDS
     IGSLNSTQVS VVGAILEYLS IVQKHSKSKL PFPQIVSYEN FMLIDASARK NLELTSTLSG
     NLKGSLLSVI DATVTNQGGR LLHKFLSTPL AEVNLINSRL QITDFFYQNL QLVENLRELV
     KLVPDIERAL SRILIAKALP KDLESIKISL KIALSIKKEL NKVLEEENIP KYLEEIYNPL
     FGDDELYDLL DSALLDDLSN SANDGGFIKS SYSTKLEELR NLIYNSSHFI EQLKLQYRQE
     TCIETLKICH NNVWGMFIEV SSKNAHKITD SKFVHKQTTT TAVRFTTTEL QTLEAKMLNA
     KTMAAALEQE ILAELCKAIS LKSEKLSHLA KSISLIDVFC NFAYISHEFN YCRPEITSDL
     AFNIVNGRHT VIEKLITKKH ESFISNDCNL QNDQRIWLIT GPNMAGKSTF LRQNAIIVIL
     AQIGCYVPAQ SAQIGVVDKL FSRIGAADDL ASGQSTFMVE MVETSVILAQ STFRSLVILD
     EIGRGTSTYD GISIAWSCLE YIHSNIRCRC LFATHYHELV DLASKLQSLK NFTVKIHDSN
     DKLSFLYKII EGAANKSYGI HVAELAGLPR IVLNRAKEIL LELEHNKADI NQSNNNITKS
     MDIAVPPYPV KTIEIIKQLN PDQLTPKEAL SIIYKIKNTI LLEEDEKMI