ID   MUTS_PARD8              Reviewed;         870 AA.
AC   A6LG92;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BDI_2998;
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000140; ABR44706.1; -; Genomic_DNA.
DR   RefSeq; WP_011967099.1; NC_009615.1.
DR   AlphaFoldDB; A6LG92; -.
DR   SMR; A6LG92; -.
DR   STRING; 435591.BDI_2998; -.
DR   EnsemblBacteria; ABR44706; ABR44706; BDI_2998.
DR   KEGG; pdi:BDI_2998; -.
DR   PATRIC; fig|435591.13.peg.2957; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; PDIS435591:G1G5A-3075-MON; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335190"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  97927 MW;  6F79E6064A2C8FFA CRC64;
     MAKVVETPLM KQYFDIKAKH PDAILLFRVG DFYEMYGEDA VIGAEILGIV QTKRANGVGQ
     HVEMAGFPHH ALDSYLPKLV RAGKRVAICD QLEDPKLTKK LVKRGITELV TPGVSINDNI
     LNHKENNFLA SIHFAKEVCG ISFLDISTGE FMTAEGSIDY IDKLLNNFSP KEVLIERGNK
     KRFEEAFGPR FFIFELDDWI FTTSAAEDRL LKHFETKNLK GFGVQHLKLG IIASGAILYY
     LDQTQHTHIS HITALSRIEE DRYVRLDKFT VRSLELVGTM NDEGTSLLDV IDKTISPMGS
     RMLRRWILFP LKDVKPIQER QEVVDYFFRE PETKELLDTQ LEQIGDLERI ISKVAVGRVS
     PREVVQLKVA LRAIEPIKEA CMASGEPSLC RIGEQLNACA LIRDRIEKEI NNDPPSLVNK
     GGIIAKGVNE ELDDLRAIAY SGKDYLLKVQ QREIELTGIP SLKIAFNNVF GYYIEVRNTH
     KDKVPANWIR KQTLVNAERY ITEELKEYEE KILGAEEKIL ALETRLFNEL VLALTEYIPP
     IQMNANLIGR IDCLLSFAKA AEANKYIRPV VSDSDKIDIK GGRHPVIEKQ LPLGEPYIAN
     DVYLDDEKQQ IIIITGPNMA GKSALLRQTA LITLMAQIGC FVPAESAHIG IVDKIFTRVG
     ASDNISVGES TFMVEMNEAS DILNNMTSRS LVLFDELGRG TSTYDGISIA WAIVEYIHEH
     PNAKAKTLFA THYHELNEME RAFKRIKNYN VSVKEVGNKV IFLRKLIPGG SEHSFGIHVA
     KMAGMPKSIV KRSNEILKQL ESENRQEGIT GKPVKAIASA AEGYQLSFFQ LDDPVLSQVR
     DEIKNLDVNN LTPLEALNKL IEIKRIITGK