ID   MUTS_PARDP              Reviewed;         878 AA.
AC   A1B095;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pden_0827;
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=318586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000489; ABL68939.1; -; Genomic_DNA.
DR   RefSeq; WP_011747167.1; NC_008686.1.
DR   AlphaFoldDB; A1B095; -.
DR   SMR; A1B095; -.
DR   STRING; 318586.Pden_0827; -.
DR   PRIDE; A1B095; -.
DR   EnsemblBacteria; ABL68939; ABL68939; Pden_0827.
DR   KEGG; pde:Pden_0827; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000361; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335191"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   878 AA;  94745 MW;  C0676C04103CA456 CRC64;
     MSDQPTPMMA QYLAIREANP GALLFYRMGD FYEMFFEDAV AAAAALDIAL TKRGTHLGEP
     IPMCGVPVHA AESYLLTLIR KGFRVAIAEQ MEDPAEAKKR GSKSVVARDV VRLVTPGTLT
     EESLLEARRH NFLASFASVR DESALAWVDI STGAFRVMPC PPARLAPELA RHAPRELLAA
     EGANLDEIAA EAGAALTELP GGSFDSSAAT RRLCALFSVE TLDGFGQFSR AELAAMGAIA
     DYLELTQKGR MPLIRPPVRE ALGGAMQIDA ATRRNLELTQ ALSGGREGSL LAAIDRSVTA
     GGARLLERRI SAPSRDLDEI HARQAAVAHL VDEPRLTADL REALSRAPDM DRALSRLALE
     RGGPRDLAAI RAGLTQGAAI AAMLGNDEIA VLAEAAHDLT GHDALIDLLD EALVAEPPLL
     ARDGGFVAPG YDEDLDETRR LRDEGRGVIA RMQADYIAET GVQSLKIKHN NVLGYFIETT
     STHAERMLAP PLNERFIHRQ TTANQIRFTT VELSELETRI LNARDRALEI EREIFARLSR
     AVLDRAGPVG QAARALAEID LTAAFADLAS GEGWVRPEVD ASRAFVIEGG RHPVVERALK
     RKGEAFVAND CALTQGETPA IWLLTGPNMA GKSTFLRQNA LIAILAQAGG FVPARRAHIG
     LVSQLFSRVG AADDLARGRS TFMVEMVETA AILNQADDHA LVILDEIGRG TATWDGLSIA
     WAVMEHLHAT NRCRALFATH YHEMTSLSAR LPGVENATVA VREWEGEVIF LHEVRKGAAD
     RSYGVQVARL AGLPPSVVDR ARDILHQLES GERQGTGKPA ALLDDLPLFR AAPAPAPAGK
     AKPSVVEDRL RSLNPDTISA REALDLVYEL RGMLDGEP