ID   MUTS_PARL1              Reviewed;         908 AA.
AC   A7HZ64;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Plav_3599;
OS   Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Parvibaculaceae; Parvibaculum.
OX   NCBI_TaxID=402881;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DS-1 / DSM 13023 / NCIMB 13966;
RX   PubMed=22675581; DOI=10.4056/sigs.2215005;
RA   Schleheck D., Weiss M., Pitluck S., Bruce D., Land M.L., Han S.,
RA   Saunders E., Tapia R., Detter C., Brettin T., Han J., Woyke T., Goodwin L.,
RA   Pennacchio L., Nolan M., Cook A.M., Kjelleberg S., Thomas T.;
RT   "Complete genome sequence of Parvibaculum lavamentivorans type strain (DS-
RT   1(T)).";
RL   Stand. Genomic Sci. 5:298-310(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000774; ABS65197.1; -; Genomic_DNA.
DR   RefSeq; WP_012112457.1; NC_009719.1.
DR   AlphaFoldDB; A7HZ64; -.
DR   SMR; A7HZ64; -.
DR   STRING; 402881.Plav_3599; -.
DR   EnsemblBacteria; ABS65197; ABS65197; Plav_3599.
DR   KEGG; pla:Plav_3599; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006377; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..908
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075558"
FT   BINDING         659..666
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   908 AA;  96441 MW;  CB311FF747A9DB26 CRC64;
     MSEPATSFTP EIPSALPSIP ADATPMMAQY LEIKARWPEA LLFYRMGDFY ELFFEDAVAA
     SAALDIALTK RGKHLGEDIP MCGVPVHSHD AYLQRLIRKG FKVAVCEQVE DPAEAKKRGA
     KSVVARAVAR LVTPGTLTED TLLDARAHNY LAALSRTGAE AGFGLAWVDV STGDFAVTSL
     APVALGAELA RLSPGELLLP ETLDEDEDLA ALLAQSGAAL TRLPAIRFES GQAERRLKSH
     LGVSALDGFG AFARAELGAM GALLDYVELT QVGRMPALMP PRRVAATDTM AIDAATRANL
     ELVRTLQGET AGSLLATMDR TVTGAGAREL ASRLAAPLTD PAAVNRRLDA VEWFHDARDM
     RARLRAGLKS APDIARALSR LSLGRGGPRD LAAIANGLAA AHGLCAALDG ASPSLLPLPE
     EIARECEAMR GTAASLQSRL AAMLAEELPL LARDGGFIAR GASPELDETR ALRDDARKLI
     AGLQAKYAGE SGIAALKIRH NNVLGYYIEV PPRHGEKLLA PPFSDSYIHR QTMANAMRFT
     TAELAGLASR IAEAAGRALE IELALFDELA AATLLEAPSL SRAAEALARL DATAALAELA
     AERRYVRPRL DASFAFDIRG GRHPVVEAAL ARTGQAFVPN DTSLSAESGG GKHIWLLTGP
     NMAGKSTFLR QNALIAIMAQ MGSFVPADEA HIGVVDRLFS RVGAADDLAR GRSTFMVEMV
     ETAAILNQAG ERSLVILDEI GRGTATFDGL SIAWATVEHL HGVNKSRALF ATHYHELTAL
     SEKLAHLANA TMRVKEWQGD VVFLHEVAPG AADRSYGIQV AKLAGLPAPV IARAQSVLAA
     LEEGGNHEAR TKLIDDLPLF SATAKPAPAV KVSAAEEELK NLNPDELSPK QALELLYKLK
     ALAAKDGE