ID   MUTS_PARMW              Reviewed;         900 AA.
AC   Q7UA23;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SYNW0078;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX569689; CAE06593.1; -; Genomic_DNA.
DR   RefSeq; WP_011126956.1; NC_005070.1.
DR   AlphaFoldDB; Q7UA23; -.
DR   SMR; Q7UA23; -.
DR   STRING; 84588.SYNW0078; -.
DR   EnsemblBacteria; CAE06593; CAE06593; SYNW0078.
DR   KEGG; syw:SYNW0078; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..900
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115154"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         714..721
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   900 AA;  98106 MW;  67DDF5D5703C28FD CRC64;
     MPGPSDDPTE IALQGNLFSD AEPTVSATGV EPSTACEAFS DMELTADAAS RPRRRAPADH
     NAADHDSNTD ESSDNSDDPA WAHHSQVDPQ QLTPMLRHYV ELKAAHPERV LLYRLGDFFE
     CFFEDAITLS RLLELTLTGK EGGKAVGRVP MAGIPHHAAE RYCGELIRRG FSVALCDQLE
     TTPAKGALLK RDITRVLTPG TVLEEGMLSS RRNNWLAAVV IEPAHRDEPF RWGLASADVS
     TGEVQVMQRQ DSDALHQQLA QLGAAELLSS TPESNPAWCP DQLRLTSVAS TPFSRPAAEA
     ALLRHYKLAN LDGLGLPELP LALRAMGGLL AYLRDTQPLE ENASVPLEVP AIVQRGDALV
     LDAQTRRNLE LTATQRDGSL QGSLLWAIDR TLTAMGGRCL RRWLEAPLMD LDAIRQRQQL
     VSTLVEQRNL RQALRRLLRP MGDLERLAGR AGAGHAGARD LVAIADGLER LPQLAARLEG
     TIIRGPDWLD DLLQPDPALQ DLASSIRHTL LESPPLSLSE GGLIHDGVDP LLDGLRNQLD
     DQDAWLSQQE KQERQRSGNS NLRLQYHRTF GYFLAVSKAK ASAVPDHWIR RQTLANEERF
     ITPALKEREG RIFQLRARAC QREYELFCTL REQVGALAAS IRRAARAVAG LDALTGLADT
     AASGAYCAPE LVEGRALSLS EARHPVVEQL LVETRFTAND VHLGSGTDLV VLTGPNASGK
     SCYLRQIGLI QLLAQIGSWV PAAKARIGIA DRIFTRVGAV DDLAAGQSTF MVEMAETANI
     LHHATELSLV LLDEIGRGTA TFDGLSIAWA VSEHLAGDLR ARTVFATHYH ELNNLANERA
     NVANFQVLVE ETGDDLLFLH RVSQGGASRS YGIEAARLAG VPTPVVQRAR QVLDQIEAAA