ID   MUTS_PARP8              Reviewed;         892 AA.
AC   B2JIT0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Bphy_1399;
OS   Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS   STM815) (Burkholderia phymatum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=391038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815;
RX   PubMed=25197461; DOI=10.4056/sigs.4861021;
RA   Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA   James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA   Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA   Bristow J., Riley M.;
RT   "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT   range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL   Stand. Genomic Sci. 9:763-774(2014).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001043; ACC70581.1; -; Genomic_DNA.
DR   RefSeq; WP_012400795.1; NZ_CADFGH010000003.1.
DR   AlphaFoldDB; B2JIT0; -.
DR   SMR; B2JIT0; -.
DR   STRING; 391038.Bphy_1399; -.
DR   EnsemblBacteria; ACC70581; ACC70581; Bphy_1399.
DR   KEGG; bph:Bphy_1399; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001192; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..892
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093612"
FT   BINDING         634..641
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   892 AA;  96589 MW;  2163C99943525249 CRC64;
     MGTQTAAASD IAQHTPMMQQ YLRIKGEHPG TLVFYRMGDF YELFFDDAEK AARLLDLTLT
     QRGASGGNPI KMAGVPHHAV EQYLAKLVKL GESVAICEQI GDPATSKGPV ERKVVRVVTP
     GTLTDAALLS DKSDTYLLAA CAGHNRRGVV TTVGLAWLNL ASGALRLAEV APDQVAAALE
     RIRPAEILVA DAPSSSDANA WSVPTGFGAT TRVPLWHFDV ASGTQRLCDQ LEVAGLDGFG
     AHSLTCACGA AGALLLYAAA TQGQQLRHVR SLKVEYESEY IGLDPSTRRN LELTETLRGT
     DSPTLCSLLD TCCTTMGSRL LRHWLHHPPR DASFAQARQQ AIGALLDSPP QASLDALCGA
     LRQISDIERI TGRLALLSAR PRDLSSLRDT FIALPELRAQ LVPLTGAADS LARIHASLEP
     PADCVDLLTR AVAQEPAAMI RDGGVIARGY DVDLDELRDI SENCGQFLID LETRERARTG
     IGNLRVEYNK VHGFYIEVTR GQTDKVPDDY RRRQTLKNAE RYITPELKTF EDKALSAQER
     ALAREKALYD ALLQSLLPFI ADCQRVASAL AELDLLAAFA ERARALDWVA PNFSATGGID
     IEQGRHPVVE AQVEQFIAND CMLNPERKLL LITGPNMGGK STFMRQTALI ALMAYVGSYV
     PARRASFGPI DRIFTRIGAA DDLAGGRSTF MVEMTEAAAI LNDATPQSLV LMDEIGRGTS
     TFDGLALAWA IARHLLAHNG CHTLFATHYF ELTQLPAEFP HAANVHLSAV EHGHGIVFLH
     AVNEGPANQS YGLQVAQLAG VPNAVIRAAR KHLAYLEQQS AGAPAPQLDL FSAPVAMLED
     ADDESIAPAL DAATRTLVER LRDIDPNDLR PRDALDLLYE LHELAKSPDA PR