ID   MUTS_PARPJ              Reviewed;         894 AA.
AC   B2SXQ9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Bphyt_2520;
OS   Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
OS   (Burkholderia phytofirmans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=398527;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17436 / LMG 22146 / PsJN;
RX   PubMed=21551308; DOI=10.1128/jb.05055-11;
RA   Weilharter A., Mitter B., Shin M.V., Chain P.S., Nowak J., Sessitsch A.;
RT   "Complete genome sequence of the plant growth-promoting endophyte
RT   Burkholderia phytofirmans strain PsJN.";
RL   J. Bacteriol. 193:3383-3384(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001052; ACD16915.1; -; Genomic_DNA.
DR   RefSeq; WP_012433511.1; NC_010681.1.
DR   AlphaFoldDB; B2SXQ9; -.
DR   SMR; B2SXQ9; -.
DR   STRING; 398527.Bphyt_2520; -.
DR   EnsemblBacteria; ACD16915; ACD16915; Bphyt_2520.
DR   KEGG; bpy:Bphyt_2520; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001739; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..894
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093613"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   894 AA;  97007 MW;  D991769E04C234BE CRC64;
     MGIQTAAAND VAQHTPMMQQ YLRIKADHPG TLVFYRMGDF YELFFEDAEK AARLLDLTLT
     QRGASAGNPI KMAGVPHHAV EQYLAKLVKL GESVAICEQI GDPATSKGPV ERKVVRVVTP
     GTLTDAALLS DKSDVYLLAM CVAHNRRGVA TSVGLAWLNL ASGALRLAEV APDQVAAALE
     RIRPAEILVA DTPSDSASWT PPVNAGALTR VPVWHFDVTS GTQRLCDQLE VAGLDGFGAH
     SLTCACGAAG ALLLYAAATQ GQQLRHVRSL KVEYESEYIG LDPATRRNLE LTETLRGTES
     PTLCSLLDTC CTTMGSRLLR HWLHHPPRES AVAQARQQAI GALLDAPPGA SIDSLRGALR
     QISDIERITG RLALLSARPR DLSSLRDTFI ALPELRTQVA AVAPNADSLA RIDASLEPPQ
     ACVELLKRAV AQEPSAMVRD GGVIARGYDA ELDELRDISE NCGQFLIDLE TRERARTGIG
     NLRVEYNKVH GFYIEVTRGQ TDKVPDDYRR RQTLKNAERY ITPELKTFED KALSAQERAL
     ARERSLYDAL LQALLPFIPD CQRVASALAE LDLLAAFGER ARALDWVAPT FSANAGIEIE
     QGRHPVVEAQ VEQFIANDCS LTPERKLLLI TGPNMGGKST FMRQTALIAL LAYVGSYVPA
     RRAAFGPIDR IFTRIGAADD LAGGRSTFMV EMTEAAAILN DATPQSLVLM DEIGRGTSTF
     DGLALAWAIA RHLLAHNGCH TLFATHYFEL TQLPAEFPQA ANVHLSAVEH GHGIVFLHAV
     SEGPANQSYG LQVAQLAGVP NAVIRAARKH LAHLEQQSAA QPAPQLDLFA TPMPMLLEDA
     DDERDAKAEP AVPPAMQELV ERLRGIDPND LRPREALDLL YELHELAAAP DADH