ID   MUTS_PARUW              Reviewed;         858 AA.
AC   Q6MBV4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=pc1221;
OS   Protochlamydia amoebophila (strain UWE25).
OC   Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC   Candidatus Protochlamydia.
OX   NCBI_TaxID=264201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWE25;
RX   PubMed=15073324; DOI=10.1126/science.1096330;
RA   Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA   Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA   Mewes H.-W., Wagner M.;
RT   "Illuminating the evolutionary history of chlamydiae.";
RL   Science 304:728-730(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX908798; CAF23945.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6MBV4; -.
DR   SMR; Q6MBV4; -.
DR   STRING; 264201.pc1221; -.
DR   PRIDE; Q6MBV4; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000529; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224387"
FT   BINDING         637..644
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  98030 MW;  618F61ED0F91BCFE CRC64;
     MFIFQLKISL FMSDFEQHSL DESKISPMMM QWHACKKMAG DAILFFRMGD FYEAFYEDAH
     LLSKELELTL TKRQEIPMSG IPFHTSEGYI DKLVAKGFRV AIAEQIEDPK KTKGLVKREV
     VRVVSPGTVI NSSLLSDKNN NFFAALVKVG QIFGLAFLDL TTGEYWVSEF TQERELLNEL
     YRLHPAEFLT SEKFKEKHAS LFEEMQQTYS FLVNTLEDWQ FEHQQAHDFL INHFKVQRLD
     GFGLSGMVAA INAAGALLNY LQETLCLPIQ HIQSIRCYSS SQFMMLDRMT QRNLELTHSL
     QDGSRRHTLL GVIDQTQTPM GARLMHHWVK QPLLKVSEIH QRQNGIQALL NHEHIVDQLQ
     NLFLQIKDIE RLMMKVSACY ATPRDLIALH FSFKPIAFIK SLLLNIPSEW INEHAQKLDP
     LSKMNALISN AIVEEPPLRL GEGKTFRQGF HRELDELREI SHDSKAWMAR YQTQIREETG
     IKTLKVGFNK MFGYFIEVSR GQIDKMPDHF IRRQTLVNAE RYITPELKEY ESKVLTAEER
     INSIESELFH QLRLEVASYT KNVLEVAQAL AKIDCLISLT NVAKKYCYTC PVIDDSSILV
     IEEGRHPVIE TVCRHEKFIP NDTYLDDQAN RLLLITGPNM AGKSTYLRQV ALIVILAQIG
     SFVPAAKAHI GIIDKVFTRI GASDDLSRGQ STFMVEMTET ANILNNATSQ SLVILDEIGR
     GTSTYDGISI AWSVAEYLLT TEKRMAKTLF ATHYWELTKL EEKVPGAVNY NVAVHEADDH
     ITFLRKIIKG GTDKSYGIHV ARLAGLPQAV LNRSKEILEH LEENANRKSA FEPTRSKKSM
     VSKVKVPSTD FQLNLFQS