ID   MUTS_PARXL              Reviewed;         894 AA.
AC   Q13X51;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Bxeno_A2800;
GN   ORFNames=Bxe_A1617;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE31338.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000270; ABE31338.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_038457717.1; NZ_CP008760.1.
DR   AlphaFoldDB; Q13X51; -.
DR   SMR; Q13X51; -.
DR   STRING; 266265.Bxe_A1617; -.
DR   EnsemblBacteria; ABE31338; ABE31338; Bxe_A1617.
DR   KEGG; bxe:Bxe_A1617; -.
DR   PATRIC; fig|266265.5.peg.2940; -.
DR   eggNOG; COG0249; Bacteria.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..894
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335132"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   894 AA;  97069 MW;  87223A9DD4DE25DE CRC64;
     MGIQTATASD VAQHTPMMQQ YLRIKAEHPG TLVFYRMGDF YELFFEDAEK AARLLDLTLT
     QRGASAGNPI KMAGVPHHAV EQYLAKLVKL GESVAICEQI GDPATSKGPV ERKVVRVVTP
     GTLTDAALLS DKNDVYLLAM CVAHNRRGVA TSVGLAWLNL ASGALRLAEL APDQVAAALE
     RIRPAEVLVA DTPGDAASWT PPVNAGALTR VPVWHFDIAS GTQRLCDQLE VAGLDGFGAH
     SLTCAWGAAG ALLLYAAATQ GQQLRHVRSL KVEYESEYIG LDPATRRNLE LTETLRGTES
     PTLCSLLDTC CTTMGSRLLR HWLHHPPRES AVAQARQQAI GALLEAPPGA GVDSLRGALR
     QISDIERITG RLALLSARPR DLSSLRDTFI ALPELRAQLA AVSPNADSLA RIDASLEPPQ
     ACVELLRRAV AEEPSAMVRD GGVIARGYDA ELDELRDISE NCGQFLIDLE TRERARTGIG
     NLRVEYNKVH GFYIEVTRGQ TDKVPDDYRR RQTLKNAERY ITPELKTFED KALSAQERAL
     ARERSLYDAL LQALLPFIPD CQRVASALAE LDLLAAFGER ARALDWVAPT FSPDAGIEIE
     QGRHPVVEAQ VEQFIANDCS LTPERKLLLI TGPNMGGKST FMRQTALIAL LAYVGSYVPA
     RRAAFGPIDR IFTRIGAADD LAGGRSTFMV EMTEAAAILN DATPQSLVLM DEIGRGTSTF
     DGLALAWAIA RHLLAHNGCH TLFATHYFEL TQLPAEFPQA ANVHLSAVEH GHGIVFLHAV
     SEGPANQSYG LQVAQLAGVP NAVIRAARKH LAYLEQQSAA QPAPQLDLFA APMPMLLEDA
     DDERDSKAEA LVPPAMQALV ERLRGIDPND LRPREALDLL YELHELAAAP DADH