ID   MUTS_PASMU              Reviewed;         860 AA.
AC   P57972;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=PM1830;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE004439; AAK03914.1; -; Genomic_DNA.
DR   RefSeq; WP_005724843.1; NC_002663.1.
DR   AlphaFoldDB; P57972; -.
DR   SMR; P57972; -.
DR   STRING; 747.DR93_105; -.
DR   EnsemblBacteria; AAK03914; AAK03914; PM1830.
DR   KEGG; pmu:PM1830; -.
DR   PATRIC; fig|272843.6.peg.1854; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115115"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   860 AA;  96069 MW;  A0ECBC3F94E08AA0 CRC64;
     MDNLDLHTPM MRQYLALKAE NPDILLFYRM GDFYELFYDD AKKAAALLDI SLTKRGQSAG
     QPIPMAGVPY HAVEGYLAKL VQLGESVAIC EQVGDPATSK GPVERQVVRI VTPGTVSDES
     LLPERQDNLI ATVYQEKDRF GLAVLDITSG RFQISEPEDR ASLQAELQRI SPVELLYCED
     FVDMALLEPF KGLRRRPIWE FELGTAIQLL NRQFHTKDLR GFGVEKAILG LCAAGCLLQY
     AKDTQRTALP HIQSLTLLQH SEHIQLDAAT RRNLELTQNL AGGSENTLAS VLDKCVTPMG
     SRLLKRWMHQ PIRQHEKLMV RQNRITALLQ QDLVAAIQPY LQQIGDMERI LARVALRSAR
     PRDLTRLRTA LEQIPYLRDI LAQQTSSDLT ALLQPIGEFS AQLDLLQRAI IDNPPMLIRD
     GGVIAEGYNA ELDEWRSLSD GATRYLEELE QRERESTGID TLKIGFNAVH GYYIQISQGQ
     AHKAPMHYVR RQTLKNAERY IIPELKTYED KVLKAKGAAL ALEKQLYEQL FDELLPHLGA
     LQLASLTLAE LDVLTNLAER AETLNYVAPQ FSDDIGVHIQ QGRHPVVEQV LNAPFIANPV
     ELHPQRHLLI ITGPNMGGKS TYMRQTALIT LMAYMGSFVP AESAVIGPID RIFTRIGASD
     DLASGRSTFM VEMTEMANIL HQATANSLVL IDEIGRGTST YDGLSLAWAC AEWLAKKLRS
     LTLFATHYFE LTVLPEQLAG SANVHLDAIE HNDTIAFMHA VQEGAASKSY GLAVAALAGV
     PQSVIKLAKQ KLAQLEKLSQ QNADQRIQDL RQLNQTQGEL ALMEEDDSKT AVWEMLEKLD
     PDELSPKQAL AYLYQLKKLV