ID   MUTS_PECAS              Reviewed;         854 AA.
AC   Q6D8C1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ECA1053;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX950851; CAG73964.1; -; Genomic_DNA.
DR   RefSeq; WP_011092651.1; NC_004547.2.
DR   AlphaFoldDB; Q6D8C1; -.
DR   SMR; Q6D8C1; -.
DR   STRING; 218491.ECA1053; -.
DR   EnsemblBacteria; CAG73964; CAG73964; ECA1053.
DR   KEGG; eca:ECA1053; -.
DR   PATRIC; fig|218491.5.peg.1062; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224372"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95103 MW;  1E02E2B267431E2F CRC64;
     MKESEGIDLS THTPMMQQYF RLKAEHPEIL LFYRMGDFYE LFFDDAKRAS QLLDISLTKR
     GASAGEPIPM AGVPHHAVEN YLARLVQMGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
     ISDEALLQEK QDNLLAAIWQ DGRGFGYATL DISSGRFRVS EPADRETMAA ELQRTNPAEL
     LYPESFESME LIDNRHGLRR RPMWEFEPDT ARQQLNLQFG TRDLTGFGVE QAKLALRAAG
     CLLQYAKDTQ RTSLPHIRGI TMERQQDGII MDAATRRNLE LTQNLSGGVE NTLAAVLDCT
     VTAMGSRMLK RWIHMPSRDI DALKQRQQAI SALQEITPDL QPYLRQVGDL ERILARLALR
     TARPRDLARM RHAFQQFPDI REQLAPLDTD SVRRLVSLIG QFDELRDLLE RAVVEAPPVL
     VRDGGVIAPG YHTELDEWRA LADGASDYLD RLEIREREKL GLDTLKVGFN GVHGYYIQVS
     RGQSHLVPIH YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKALY DELFDLLLPH
     LAELQQSAAA LAELDVLTNL AERADTLNYV CPTLSDKPGI KIAGGRHPVV EQVLREPFIS
     NPLSLSPQRR MLIITGPNMG GKSTYMRQAA LIVLMAHIGC FVPADQAVIG PVDRIFTRVG
     AADDLASGRS TFMVEMTETA NILHNATENS LVLMDEIGRG TSTYDGLSLA WACAESLANR
     IKAMTLFATH YFELTTLPEK MEGVVNVHLD AREHGDTIAF MHSVQDGAAS KSYGLAVAAL
     AGVPKEVIKR ARQKLKELET LSNNASSSHI DGAQLALLNT DEPSPAIEAL EAIDPDALTP
     RQALDWLYQL KKML