ID   MUTS_PECCP              Reviewed;         854 AA.
AC   C6DAK6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PC1_0964;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001657; ACT12014.1; -; Genomic_DNA.
DR   RefSeq; WP_012773651.1; NC_012917.1.
DR   AlphaFoldDB; C6DAK6; -.
DR   SMR; C6DAK6; -.
DR   STRING; 561230.PC1_0964; -.
DR   PRIDE; C6DAK6; -.
DR   EnsemblBacteria; ACT12014; ACT12014; PC1_0964.
DR   KEGG; pct:PC1_0964; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202741"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95212 MW;  7CEEBDB15D02DB15 CRC64;
     MKDSTDKDFT AHTPMMQQYF RLKAEHPEIL LFYRMGDFYE LFYDDAKRAS QLLDISLTKR
     GASAGEPIPM AGVPHHAVEN YLARLVQMGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
     ISDEALLQEK QDNLLAAIWQ DSRGFGYATL DISSGRFRVS EPTDRETMAA ELQRTNPAEL
     LYPESFESMD LIENRHGLRR RPLWEFEPDT ARQQLNLQFG TRDLTGFGVE QAKLALRAAG
     CLLQYAKDTQ RTSLPHIRGI TMERQQDGII MDAATRRNLE LTQNLSGGVE NTLAAVLDCT
     VTAMGSRMLK RWIHMPSRDI DALQQRQQAI SALQDITPDL QPYLRQVGDL ERILARLALR
     TARPRDLARM RHAFQQFPDI REQLAPLDID SVRRLVSLIG QFDELRDLLE RAVIEAPPVL
     VRDGGVIAPG YNAELDEWRA LADGASDYLD RLEIREREKL GLDTLKVGFN GVHGYYIQVS
     RGQSHLVPIH YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKALY DELFDLLLPH
     LAELQQSAAA LAELDVLTNL AERADTLNYV CPTLSDKPGI KITGGRHPVV EQVLREPFIS
     NPLSLSPQRR MLIITGPNMG GKSTYMRQAA LIVLMAHIGC FVPADQAVIG PVDRIFTRVG
     AADDLASGRS TFMVEMTETA NILHNATENS LVLMDEIGRG TSTYDGLSLA WACAENLANR
     IKAMTLFATH YFELTTLPEK MEGVVNVHLD AREHGDTIAF MHSVQDGAAS KSYGLAVAAL
     AGVPKEVIKR ARQKLKELEM LSNNASSSHI DGAQLALLGN DEPSPAIEAL EAIDPDALTP
     RQALDWLYQL KKML